Langerin

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Langerin
Langerin
according to PDB  3C22
other names
  • CD207
  • C-type lectin domain family 4 member K

Existing structural data : 3C22 , 3KQG , 3P5D , 3P5E , 3P5F , 3P5G , 3P5H , 3P5I , 3P7F , 3P7G , 3P7H , 4AK8 , 4N32 , 4N33 , 4N34 , 4N35 , 4N36 , 4N37 , 4N38

Mass / length primary structure 328 amino acids , 36.7 kDa
Secondary to quaternary structure Homotrimer
Identifier
External IDs
Orthologue
human House mouse
Entrez 50489 246278
Ensemble ENSG00000116031 ENSMUSG00000034783
UniProt Q9UJ71 Q8VBX4
Refseq (mRNA) NM_015717 NM_144943
Refseq (protein) NP_056532 NP_659192
Gene locus Chr 2: 70.83 - 70.84 Mb Chr 6: 83.67 - 83.68 Mb
PubMed search 50489 246278

Langerin (synonym CD207 , C-type lectin domain family 4 member K ) is a protein in Langerhans cells .

properties

Langerin is a type II transmembrane protein and a C-type lectin . In addition to Langerhans cells Langerin is also of CD103 -positive dendritic cells of the skin and CD8 -positive dendritic cells of the spleen expressed . Langerin is localized intracellularly in Birbeck granules and initiates their formation. As a lectin, Langerin binds mannose . Presumably, by binding mannose, Langerin serves as a resistance factor for the immune system , e.g. B. in HIV -1, mycobacteria and Candida . While Langerin inhibits infection of dendritic cells with HIV-1 through the skin, the C-type lectin DC-SIGN leads to an intensification of the infection.

Individual evidence

  1. ↑ J. Valladeau, O. Ravel, C. Dezutter-Dambuyant, K. Moore, M. Kleijmeer, Y. Liu, V. Duvert-Frances, C. Vincent, D. Schmitt, J. Davoust, C. Caux, p Lebecque, S. Saeland: Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. In: Immunity. Volume 12, Number 1, January 2000, ISSN  1074-7613 , pp. 71-81, PMID 10661407 .
  2. ↑ LM van den Berg, SI Gringhuis, TB Geijtenbeek: An evolutionary perspective on C-type lectins in infection and immunity. In: Annals of the New York Academy of Sciences . Volume 1253, April 2012, ISSN  1749-6632 , pp. 149-158, doi : 10.1111 / j.1749-6632.2011.06392.x , PMID 22288724 .
  3. ^ L. de Witte, A. Nabatov, M. Pion, D. Fluitsma, MA de Jong, T. de Gruijl, V. Piguet, Y. van Kooyk, TB Geijtenbeek: Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. In: Nature Medicine . Volume 13, Number 3, March 2007, ISSN  1078-8956 , pp. 367-371, doi : 10.1038 / nm1541 , PMID 17334373 .
  4. ↑ LM van den Berg, TB Geijtenbeek: Antiviral immune responses by human Langhans cells and dendritic cells in HIV-1 infection. In: Advances in Experimental Medicine and Biology . Volume 762, 2013, ISSN  0065-2598 , pp. 45-70, doi : 10.1007 / 978-1-4614-4433-6_2 , PMID 22975871 .