List of human CD antigens
Well over three hundred different clusters of differentiation have now been described; some important representatives are listed below:
| CD | Synonyms | Cell type | Function of the protein |
|---|---|---|---|
| CD1a | Thymocytes, dendritic cells | Antigen presentation | |
| CD1b | Thymocytes, dendritic cells | Antigen presentation | |
| CD1c | Thymocytes, dendritic cells | Antigen presentation | |
| CD1d | Thymocytes, dendritic cells | Antigen presentation | |
| CD1e | Thymocytes, dendritic cells | Antigen presentation | |
| CD2 | SRBC, T11 | T cells , NK cells | Adhesion , T-cell activation |
| CD3 | T3E, TCRE | T cells | Signal transduction, T cell receptor (TCR) |
| CD4 | T helper cells | Binding of MHC -II | |
| CD5 | T1, Leu1 | T, B cell subpopulation | Binding of CD72 |
| CD6 | T12, Tp120 | T, B cells | T cell activation |
| CD7 | GP40, Leu-9, Tp40, TP41 | Blood stem cells , subpopulation of T cells | Signal transduction |
| CD8 | Leu2, MAL, p32 | Cytotoxic T cells (CTL) | Binding of MHC -I |
| CD9 | 5H9, BA2, BTCC-1, DRAP-27, GIG2, MIC3, MRP-1, p24, Tspan-29 | Blood stem cells | Activation of platelets |
| CD10 | Atriopeptidase, CALLA (Common acute lymphocytic leukemia antigen), Enkephalinase, EPN, NEP, Neprilysin , Neutral endopeptidase | Immature and some mature B cells, lymphoid progenitor cells, granulocytes | Degradation of small peptides, etc. a. of amyloid-beta peptide, bradykinin , substance P and natriuretic peptides , inhibitor and the like. a. Sacubitril |
| CD11a | all leukocytes | Cell adhesion via ICAM-1 | |
| CD11b | lots of leukocytes | Cell adhesion, mediation of phagocytosis | |
| CD11c | Phagocytes | activation | |
| CD12 | |||
| CD13 | Aminopeptidase N (APN), ANPEP, GP150 | Monocytes , granulocytes , epithelial cells, mesenchymal stem cells | |
| CD14 | Monocytes | Binding of lipopolysaccharides | |
| CD15 | SSEA-1, LewisX | Granulocytes , Hodgkin lymphoma , primordial germ cells | Ligand for selectins |
| CD16a | Phagocytes | Fcγ receptor IIIa: binding of F c domains of IgG , mediates phagocytosis | |
| CD16b | Phagocytes | Fcγ receptor IIIb: binding of F c domains of IgG | |
| CD17 | |||
| CD18 | Leukocytes | Cell adhesion , leukodiapedesis | |
| CD19 | all B cells | B-cell co-receptor, substantial functions in B-cell homeostasis, activation, differentiation | |
| CD20 | B cells | B cell activation | |
| CD21 | B cells | B-cell co-receptor, binds C3d and C3bi of the complement system , B-cell activation; Epstein-Barr virus receptor | |
| CD22 | Monocytes , granulocytes , B cells | Inhibition of the BCR (B-cell receptor) signal by CD22 (recognizes mannose ) when foreign antigen is on one's own body cell. This prevents signal conduction. CD22 knockout causes autoimmune diseases | |
| CD23 | B cells, activated macrophages , eosinophils , B-CLL | Growth, activation and differentiation of B cells, IgE-mediated immune reactions (low-affinity IgE receptor) | |
| CD24 | expresses v. a. on immature cells ( hematopoietic stem cells , but also immature neurons, keratinocytes, etc.) | ||
| CD25 | Activated immune cells, regulatory T cells | Alpha chain of the interleukin-2 receptor | |
| CD26 | Dipeptidyl Peptidase IV (DPPIV) | ||
| CD27 | Plasma cells , memory cells (effector B cells), T cells (naive T cells, effector T cells) | Hypermutation & class change (in B cells), proliferation & differentiation (in T cells) | |
| CD28 | T cells | Binding of B7 to "professional" antigen-presenting cells (activated B cells , dendritic cells , macrophages ), T cell co-activation | |
| CD29 | |||
| CD30 | Hodgkin lymphoma , anaplastic large cell lymphoma (ALCL), some malignant melanomas and NHL, activated lymphocytes | Apoptosis | |
| CD31 | Endothelial cells | ||
| CD32a | Fcγ receptor IIa: receptor for F c domains of IgG , mediates phagocytosis | ||
| CD32b | Fcγ receptor IIb: receptor for F c domains of IgG , mediates phagocytosis | ||
| CD33 | Monocytes , myeloid progenitor cells | presumably modulation of inflammatory immune responses by weakening tyrosine kinase signaling pathways and thus suppressing the production of inflammatory cytokines. | |
| CD34 | Hematopoietic stem cells , endothelial cells | Glycosylated type I membrane protein, which is only expressed on a few bone marrow cells, the hematopoietic stem cells. Although the protein has been studied since the late 1980s, its exact function has not yet been clarified. It is believed to have a role in the regulation of cell adhesion and cell migration activities. Ligand for L-selectin / CD62L , CD34 enrichment . | |
| CD35 | Monocytes | ||
| CD36 | Monocytes | ||
| CD37 | Monocytes | ||
| CD38 | Monocytes | ||
| CD39 | ENTPD | Lymphocytes, dendritic cells, macrophages | Ca 2+ and Mg 2+ dependent, membrane-bound enzyme that converts ATP and ADP to AMP. |
| CD40 | B cells, macrophages | activation | |
| CD41 | ITGA2B, gpIIb | Megakaryocytes , platelets | CD41 is a receptor for fibrinogen, vitronectin and fibronectin. CD41 and CD61 (gpIIIa, ITGB3) form a receptor that is expressed on the blood platelets. Absence of CD41 / CD61 on platelets leads to a disruption of blood clotting. It has recently become known that it is also expressed on haematopoietic progenitor cells. |
| CD42 | Glycoprotein Ib, GPIb | Platelets | Membrane receptor for von Willebrand factor and thrombin. Part of the activation cascade of platelets. |
| CD43 | |||
| CD44 | |||
| CD45 | all leukocytes | Tyrosine phosphatase, two different isoforms with different close associations to the T-cell receptor (RA = low, RO = strong) | |
| CD46 | all (examined) nucleated endogenous cells | Membrane Cofactor Protein (MCP), binds complement factors C3b and C4b and protects the cells from lysis by the complement system. Regulation of the inflammatory response by changing the T-cell response. Signal transduction.
Serves as a receptor for seven different pathogens, including B-type adenoviruses , herpes virus 6 (HHV6) and Streptococcus pyogenes . |
|
| CD47 | |||
| CD48 | |||
| CD49a | |||
| CD49b | |||
| CD49c | |||
| CD49d | |||
| CD49e | |||
| CD49f | |||
| CD50 | |||
| CD51 | |||
| CD52 | Foreign body giant cells | ||
| CD53 | |||
| CD54 | ICAM-1 | Endothelial cells, immune cells | Glycoprotein, interaction with integrins CD11a / CD18 and CD11b / CD18 |
| CD55 | many cells | Decay-accelerating factor (DAF), binds complement factor C5 and protects the cells from lysis by the complement system | |
| CD56 | NCAM | NK cells | adhesion |
| CD57 | |||
| CD58 | |||
| CD59 | many cells | Inhibition of the Membrane Attack Complex of the complement system | |
| CD60 | |||
| CD61 | |||
| CD62 | |||
| CD63 | |||
| CD64a | Fcγ receptor Ia: receptor for F c domains of IgG , mediates phagocytosis | ||
| CD64b | Fcγ receptor Ib: receptor for F c domains of IgG , mediates phagocytosis | ||
| CD64c | Fcγ receptor Ic: receptor for F c domains of IgG , mediates phagocytosis | ||
| CD65 | |||
| CD66a | |||
| CD66b | |||
| CD66c | |||
| CD66d | |||
| CD66e | |||
| CD66f | |||
| CD67 | |||
| CD68 | Macrophages | Immunohistochemical detection | |
| CD69 | activated T cells | Activation marker | |
| CD71 | many cells | Transferrin receptor | |
| CD72 | |||
| CD73 | |||
| CD74 | |||
| CD75 | |||
| CD80 | professional antigen presenting cells | corresponds to B7 .1, costimulation of T cells by binding to CD28 , stimulates the expression of IL2R and thus T cell proliferation | |
| CD82 | epithelial cells, leukocytes | Differentiation markers, tumor suppressor genes, more strongly expressed in well-differentiated carcinomas | |
| CD83 | dendritic cells, activated T cells, thymic stromal cells | Regulation of the T cell response, lymphocyte development | |
| CD84 | |||
| CD85 | |||
| CD86 | professional antigen presenting cells | corresponds to B7 .2, costimulation of T cells by binding to CD28 , stimulates the expression of IL2R and thus T cell proliferation | |
| CD87 | |||
| CD88 | |||
| CD89 | Monocytes, macrophages, neutrophils and eosinophils | Fcα receptor : binds the Fc domain of IgA | |
| CD90 | |||
| CD91 | |||
| CD92 | |||
| CD93 | |||
| CD95 | many cells | Apoptosis (FAS, APO1) | |
| CD97 | Leukocytes, lymphocytes, hematopoietic cells, thyroid carcinoma cells, colon carcinoma cells, squamous cell carcinoma of the oral cavity | Adhesion, angiogenesis (frgl.), Anti-apoptosis (frgl.), Markers for dedifferentiation in carcinomas, interacts with CD55 (ligand) | |
| CD98 | |||
| CD99 | |||
| CD100 | |||
| CD101 | |||
| CD105 | Endothelium , macrophages | regulatory component of the TGFβ receptor | |
| CD117 | c-Kit , KIT | including T cells , mast cells , hematopoietic stem cells | Cytokine receptor for SCF |
| CD120a | TNF receptor type 1 (TNFR1) | ||
| CD120b | TNF receptor type 2 (TNFR2) | ||
| CD127 | regulatory T cells | α chain of the interleukin 7 receptor (IL-7Rα) | |
| CD132 | common gamma chain | Cytokine receptor subunit (IL-2, IL-4, IL-7, IL-9, IL-15) | |
| CD133 | Hemapoietic stem cells and EPC | ||
| CD134 | OX40 | activated T cells | belongs to the TNF receptor family |
| CD148 | Marginal Zone (MZ) B cells | Function ??? | |
| CD152 | Activated T cells | Receptor for B7, negative regulator of T cell activation ( CTLA-4 ) | |
| CD154 | Activated T h cells | co-stimulating B-cell activator ( CD40 ligand) | |
| CD171 | L1CAM, NCAM-L1 | Nerve cells, Schwann cells, tumor cells | neuronal cell adhesion molecule , role in the development of the nervous system (axon growth, neuronal migration and differentiation ), interaction with integrins ; Expressed on particularly malignant and aggressive tumor cells (e.g. endometrial carcinoma , breast carcinoma ) |
| CD235a | Glycophorin A, GYPA | Erythrocytes | Membrane protein from erythrocytes. Part of the MNS blood group system |
literature
- T. Mustafa, T. Klonisch, S. Hombach-Klonisch, A. Kehlen, C. Schmutzler, J. Koehrle, O. Gimm, H. Dralle, C. Hoang-Vu: Expression of CD97 and CD55 in human medullary thyroid carcinomas . In: International Journal of Oncology . Volume 24, Number 2, February 2004, pp. 285-294, ISSN 1019-6439 . PMID 14719104 .
- T. Mustafa, A. Eckert, T. Klonisch, A. Kehlen, P. Maurer, M. Klintschar, M. Erhuma, R. Zschoyan, O. Gimm, H. Dralle, J. Schubert, C. Hoang-Vu: Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas. In: Cancer Epidemiology, Biomarkers & Prevention . Volume 14, Number 1, January 2005, pp. 108-119, ISSN 1055-9965 . PMID 15668483 .
- M. Erhuma, M. Köbel, T. Mustafa, J. Wulfänger, H. Dralle, C. Hoang-Vu, J. Langner, B. Seliger, A. Kehlen: Expression of neutral endopeptidase (NEP / CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues. In: International journal of cancer. Journal international du cancer. Volume 120, Number 11, June 2007, pp. 2393-2400, ISSN 0020-7136 . doi : 10.1002 / ijc.22252 . PMID 17294442 .
- Z. Chen, T. Mustafa, B. Trojanowicz, M. Brauckhoff, O. Gimm, C. Schmutzler, J. Köhrle, HJ Holzhausen, A. Kehlen, T. Klonisch, R. Finke, H. Dralle, C. Hoang -Vu: CD82, and CD63 in thyroid cancer. In: International journal of molecular medicine. Volume 14, Number 4, October 2004, pp. 517-527, ISSN 1107-3756 . PMID 15375577 .
Individual evidence
- ↑ "Entrez genes: ANPEP alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)"
- ↑ C. Lange, Z. Li, L. Fang, C. Baum, B. Fehse: CD34 modulates the trafficking behavior of hematopoietic cells in vivo. In: Stem Cells and Development . Volume 16, Number 2, April 2007, pp. 297-304, ISSN 1547-3287 . doi : 10.1089 / scd.2006.0056 . PMID 17521240 .
- ↑ Simon C. Robson, Yan Wu, Xiaofeng Sun, Christoph Knosalla, Karen Dwyer, Keiichi Enjyoji: Ectonucleotidases of CD39 Family Modulate Vascular Inflammation and Thrombosis in Transplantation. In: Seminars in Thrombosis and Hemostasis 2005; 31 (2): 217-233 doi : 10.1055 / s-2005-869527 .
- ↑ http://www.vetmed.wsu.edu/tkp/search.aspx , List of All Clusters of Differentiation, Washington State University page, accessed May 10, 2012
- ↑ http://www.ebioscience.com/mouse-cd41-antibody-purified-ebiomwreg30.htm , manufacturer's website for CD41 monoclonal antibodies, accessed on May 11, 2012
- ↑ Joseph R. SLUPSKY, Aura S. KAMIGUTI, Nicholas P. RHODES, John C. CAWLEY, Andrew RE SHAW and Mirko ZUZEL: The Platelet Antigens CD9, CD42 and Integrin αIIbβIIIa Can be Topographically Associated and Transduce Functionally Similar Signals. In: European Journal of Biochemistry Volume 244, Issue 1, pages 168-175, 1997, doi : 10.1111 / j.1432-1033.1997.00168.x .
- ↑ Rosemary L. Sparrow, Geraldine Healey, Katherine A. Patton, Margaret F. Veal: Red blood cell age determines the impact of storage and leukocyte burden on cell adhesion molecules, glycophorin A and the release of annexin V In: Transfusion and Apheresis Science . Volume 34, Issue 1, February 2006, Pages 15-23 doi : 10.1016 / j.transci.2005.09.006
- ↑ http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2993