Fcε receptor II
| Low affinity immunoglobulin epsilon Fc receptor | ||
|---|---|---|
|
||
| according to PDB 1T8C | ||
| other names |
BLAST-2, CD23, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor |
|
| Properties of human protein | ||
| Mass / length primary structure | 321 amino acids , 36,469 Da | |
| Identifier | ||
| External IDs | ||
Fcε receptor II ( FcεRII ) is a surface protein from the group of Fc receptors .
properties
Fcε receptor II is a type C lectin and binds immunoglobulin E (IgE) and complement receptor 2 (CD21). It also binds to MHCII and integrins . It is formed by B cells , macrophages , eosinophils , follicular dendritic cells and platelets and is involved in the regulation of the formation of IgE. The Fcε receptor II binds calcium ions and is glycosylated and palmitoylated . The extracellular area is called sCD23 after it has been released by ectodomain shedding .
Web links
Individual evidence
- ^ A b M. Acharya, G. Borland, AL Edkins, LM Maclellan, J. Matheson, BW Ozanne, W. Cushley: CD23 / FcεRII: molecular multi-tasking. In: Clinical and experimental immunology. Volume 162, number 1, October 2010, pp. 12-23, doi : 10.1111 / j.1365-2249.2010.04210.x , PMID 20831712 , PMC 2990925 (free full text).