CD molecule 38
| ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase 1 | ||
|---|---|---|
|
||
| according to PDB 1YH3 | ||
| other names |
2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase / 2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, CD38 |
|
| Properties of human protein | ||
| Mass / length primary structure | 300 amino acids , 34,328 Da | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.2.2.6 | |
| Orthologue (human) | ||
| Entrez | 952 | |
| Ensemble | ENSG00000004468 | |
| UniProt | P28907 | |
| Refseq (mRNA) | NM_001775.3 | |
| Refseq (protein) | NP_001766.2 | |
| PubMed search |
952
|
|
ADP-ribosylcyclase / cADPR-hydrolase 1 (synonym CD38 ) is a surface protein from the group of hydrolases .
properties
CD38 catalyzes the reaction of nicotinamide adenine dinucleotide (NAD) to cADP-ribose (cADPR) and back, as well as the reaction of NADP and nicotinate to nicotinic acid adenine dinucleotide phosphate and nicotinamide . cADPR is a secondary messenger substance . CD38 is glycosylated . The daratumumab antibody binds to CD38 and is being studied in the treatment of multiple myeloma . It is mainly formed in the pancreas , liver , kidneys , brain , testes and ovaries , placenta and by malignant lymphomas and neuroblastomas .
Web links
Individual evidence
- ^ NW van de Donk, ML Janmaat, T. Mutis, JJ Lammerts van Bueren, T. Ahmadi, AK Sasser, HM Lokhorst, PW Parren: Monoclonal antibodies targeting CD38 in hematological malignancies and beyond. In: Immunological reviews. Volume 270, number 1, March 2016, pp. 95–112, doi : 10.1111 / imr.12389 , PMID 26864107 , PMC 4755228 (free full text).