Stem cell factor
| Stem cell factor | ||
|---|---|---|
|
||
| Surface model of SCF dimer (green) on the receptor dimer according to PDB 2E9W | ||
| Properties of human protein | ||
| Mass / length primary structure | 248 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Isoforms | 3 | |
| Identifier | ||
| Gene names | KITLG ; MGF; SCF | |
| External IDs | ||
| Occurrence | ||
| Homology family | Kit ligand | |
| Parent taxon | Terrestrial vertebrates | |
The stem cell factor (also stem cell factor , SCF , kit ligand or steel factor ) is a protein from the cytokine family that is of crucial importance for the survival, proliferation and differentiation of stem cells , especially hematopoietic stem cells and progenitor cells . The stem cell factor exists in two active forms, a cell membrane-bound and a free variant. The free variant is formed from the membrane-bound stem cell factor by metalloproteases . The stem cell factor mediates its effects by activating the tyrosine kinase KIT .
literature
- MA Smith, EL Court, JG Smith: Stem cell factor: laboratory and clinical aspects . In: Blood Reviews . tape 15 , no. 4 , December 1, 2001, p. 191-197 , doi : 10.1054 / blre.2001.0167 , PMID 11792120 .
Individual evidence
- ↑ Kenneth M. Murphy, Paul Travers, Mark Walport: Janeway - Immunology . 7th edition. Springer Spectrum, Berlin 2014, ISBN 978-3-662-44227-2 , pp. 330 (corrected reprint 2014).