Siglec-3
| Siglec-3 | ||
|---|---|---|
| other names |
Sialic acid-binding Ig-like lectin 3, Siglec-3, Myeloid cell surface antigen CD33 |
|
| Properties of human protein | ||
| Mass / length primary structure | 364 amino acids , 39,825 Da | |
| Identifier | ||
| External IDs | ||
Siglec-3 (from English sialic acid – binding immunoglobulin-like lectin , synonym CD33 ) is a surface protein .
properties
Siglec-3 is a cell adhesion molecule and lectin from the immunoglobulin superfamily in myeloid cells and preferentially binds alpha-2,6-linked sialic acid . In the course of the immune response , Siglec-3 serves as an inhibitory receptor through intracellular recruitment of protein phosphatases via the SH2 domain . Siglec-3 has a cellular ITIM motif. It is glycosylated and phosphorylated . Gemtuzumab (IgG4-κ antibody hP67.6 ) and vadastuximab bind to Siglec-3.
Web links
Individual evidence
- ↑ F. Garnache-Ottou, L. Chaperot, S. Biichle, C. Ferrand, JP Remy-Martin, E. Deconinck, PD de Tailly, B. Bulabois, J. Poulet, E. Kuhlein, MC Jacob, V. Salaun , M. Arock, B. Drenou, F. Schillinger, E. Seilles, P. Tiberghien, JC Bensa, J. Plumas, P. Saas: Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells . In: Blood. Volume 105, Number 3, February 2005, pp. 1256-1264, doi : 10.1182 / blood-2004-06-2416 , PMID 15388576 .