CAMPATH 1 antigen
| Cambridge Pathogen-1 antigen | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 12 amino acids | |
| Precursor | (61 aa; 6.6 kDa) | |
| Identifier | ||
| Gene names | CD52 ; CDw52, HE5 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Old world monkeys | |
| Orthologue (human) | ||
| Entrez | 1043 | |
| Ensemble | ENSG00000169442 | |
| UniProt | P31358 | |
| Refseq (mRNA) | NM_001803 | |
| Refseq (protein) | NP_001794 | |
| Gene locus | Chr 1: 26.32 - 26.32 Mb | |
| PubMed search |
1043
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The CAMPATH 1 antigen ( CD52 ) is a surface protein on mature lymphocytes that is also found on epithelial cells of the male genital tract, but is very specific for lymphocytes. For this reason, it is the target for the antibody alemtuzumab , which is used against chronic lymphocytic leukemia and other diseases in which lymphocytes are abnormally changed. The reason for the high specificity and the effectiveness of the antibody is not known.
The protein segment CD52 is a 12 amino acid long peptide which is split off from a 61 amino acid long propeptide and bound to carbohydrates to form a surface glycoprotein. Its amino acid sequence:
- Gly-Gln-Asn-Asp-Thr-Ser-Gln-Thr-Ser-Ser-Pro-Ser
See also
- Cluster of differentiation
- Drug alemtuzumab (trade name MabCampath®)
Individual evidence
- ↑ CAMPATH 1 antigen. In: Online Mendelian Inheritance in Man . (English).
- ↑ UniProt P31358 .