PTPRC
| PTPRC | ||
|---|---|---|
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| according to PDB 1YGR , in two views | ||
| other names |
CD45, Leukocyte common antigen, L-CA, Receptor-type tyrosine-protein phosphatase C |
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| Properties of human protein | ||
| Mass / length primary structure | 1,304 amino acids , 147,254 Da | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.1.3.48 | |
| Orthologue (human) | ||
| Entrez | 5788 | |
| Ensemble | ENSG00000081237 | |
| UniProt | P08575 | |
| Refseq (mRNA) | NM_001267798.1 | |
| Refseq (protein) | NP_001254727.1 | |
| PubMed search |
5788
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The receptor type tyrosine protein phosphatase C (synonym CD45 , PTPRC ) is a surface protein from the group of protein phosphatases .
properties
PTPRC dephosphorylates phosphotyrosine residues in proteins . It binds to DPP4 and is involved in the activation of T cells , whereupon SKAP1 and Fyn are bound and dephosphorylated. It is glycosylated and phosphorylated . The glycosylation of PTPRC changes, and with it the protein-protein interactions . In T cells, Lck is dephosphorylated by PTPRC, whereas in B cells it is Lyn . In T cells, the ability to activate the T cell receptor is increased.
Web links
Individual evidence
- ↑ LA Earl, LG Baum: CD45 glycosylation controls T-cell life and death. In: Immunology and cell biology. Volume 86, Number 7, October 2008, pp. 608-615, doi : 10.1038 / icb.2008.46 , PMID 18607388 .
- ↑ a b A. E. Saunders, P. Johnson: Modulation of immune cell signaling by the leukocyte common tyrosine phosphatase, CD45. In: Cellular signaling. Volume 22, Number 3, March 2010, pp. 339-348, doi : 10.1016 / j.cellsig.2009.10.003 , PMID 19861160 .