O -phospho- L -tyrosine

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Structural formula
Structural formula of O-phospho-L-tyrosine
General
Surname O -phospho- L -tyrosine
other names
  • Phosphotyrosine
  • L -3- (4-hydroxyphenyl) alanine-4'-phosphate
  • L- tyrosine- O- phosphate
Molecular formula C 9 H 12 NO 6 P
Brief description

colorless powder

External identifiers / databases
CAS number 21820-51-9
PubChem 30819
ChemSpider 28593
DrugBank DB01962
Wikidata Q19805940
properties
Molar mass 261.17 g mol −1
Physical state

firmly

safety instructions
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

O -phospho- L -tyrosine is a chemical compound from the group of non-proteinogenic amino acids .

properties

Phosphotyrosine is produced in the course of a post-translational modification by phosphorylation of tyrosines in proteins . As a result, they appear as a subsequent modification in proteins. The phosphorylation reaction is catalyzed by a tyrosine kinase . The phosphorylation is split off by hydrolysis by tyrosine phosphatases . In addition, degradation can take place by ubiquitination .

Proteins with the protein domain SH2 bind to phosphotyrosine.

Individual evidence

  1. ↑ a b c data sheet O-Phospho-L-tyrosine, from Sigma-Aldrich , accessed on February 19, 2018 ( PDF ).
  2. ↑ JA Cooper, T. Kaneko, SS Li: Cell regulation by phosphotyrosine-targeted ubiquitin ligases. In: Molecular and cellular biology. Volume 35, number 11, June 2015, pp. 1886-1897, doi : 10.1128 / MCB.00098-15 , PMID 25776560 , PMC 4420928 (free full text).
  3. ^ BA Liu, PD Nash: Evolution of SH2 domains and phosphotyrosine signaling networks. In: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. Volume 367, number 1602, September 2012, pp. 2556-2573, doi : 10.1098 / rstb.2012.0107 , PMID 22889907 , PMC 3415846 (free full text).