Macrosialin
| Macrosialin | ||
|---|---|---|
| other names |
Gp110, CD68 antigen |
|
| Properties of human protein | ||
| Mass / length primary structure | 354 amino acids , 37,408 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 968 | |
| Ensemble | ENSG00000129226 | |
| UniProt | P34810 | |
| Refseq (mRNA) | NM_001040059.1 | |
| Refseq (protein) | NP_001035148.1 | |
| PubMed search |
968
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Macrosialin (synonym CD68 ) is a surface protein from the group of LAMP proteins and a cell adhesion molecule .
properties
CD68 immunostaining of macrophages and giant cells in xanthogranulomatous pyelonephritis
Macrosialin is produced by monocytes and macrophages (and their tissue-specific resident counterparts, histiocytes , giant cells , Kupffer cells and osteoclasts ) and is a cell type marker . It is also produced by lymphocytes , fibroblasts and endothelial cells . In addition, it is also formed by various tumors to form cell contacts . Macrosialin is glycosylated .
Macrosialin binds to oxidized LDL , phosphatidylserine and to apoptotic cells.
Applications
CD68 immunostaining is used in the diagnosis of malignant histiocytosis , histiocytic sarcoma, and Gaucher's disease .
Web links
Individual evidence
- ^ A b D.A. Chistiakov, MC Killingsworth, VA Myasoedova, AN Orekhov, YV Bobryshev: CD68 / macrosialin: not just a histochemical marker. In: Laboratory investigation; a journal of technical methods and pathology. Volume 97, number 1, January 2017, pp. 4–13, doi : 10.1038 / labinvest.2016.116 , PMID 27869795 .
- ^ Osterne R, Matos-Brito R, Alves AP: Oral Granulocytic Sarcoma: A case report Archived from the original on March 6, 2009. In: Med Oral Patol Oral Cir Bucal . 14, No. 5, February 2009, pp. E232-5. PMID 19218902 .
- ↑ Holness CL, Simmons DL: Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins . In: Blood . 81, No. 6, March 1993, pp. 1607-13. PMID 7680921 .
- ↑ Anthony Leong, Kumarason Cooper, Joel Leong: Manual of Diagnostic Cytology , 2nd edition, Greenwich Medical Media, Ltd., 2003, ISBN 1-84110-100-1 , pages 135-136.
- ↑ Manduch M, Dexter DF, Jalink DW, Vanner SJ, Hurlbut DJ: Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: Report of a case with osteochondroid differentiation . In: Pathol. Res. Pract. . 205, No. 5, January 2009, pp. 353-9. doi : 10.1016 / j.prp.2008.11.006 . PMID 19147301 .