Integrin α-IIb

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Integrin alpha-IIb
other names

GPalpha IIb, GPIIb, ITGA2B

Existing structure data : PDB  1DPK , PDB  1DPQ , PDB  1JX5

Properties of human protein
Mass / length primary structure 1,039 amino acids , 113,377 Da
Identifier
External IDs

Integrin α-IIb (synonym CD41 ) is a surface protein from the group of integrins .

properties

Integrin α-IIb is a cell adhesion molecule and, together with integrin β-3, forms a heterodimeric receptor for fibronectin , fibrinogen , plasminogen , prothrombin , thrombospondin and vitronectin . Integrin α-IIb binds to the amino acid sequence RGD in various proteins and to HHLGGGAKQAGDV in the γ chain of fibrinogen. It is formed by platelets , megakaryocytes, and HSC ( pre-HSC type II ). Integrin α-IIb is glycosylated and has a pyrrolidone carboxylic acid .

Web links

Individual evidence

  1. ↑ A. Liakhovitskaia, S. Rybtsov, T. Smith, A. Batsivari, N. Rybtsova, C. Rode, M. de Bruijn, F. Buchholz, S. Gordon-Keylock, S. Zhao, A. Medvinsky: Runx1 is required for progression of CD41 + embryonic precursors into HSCs but not prior to this. In: Development. Volume 141, number 17, September 2014, pp. 3319-3323, doi : 10.1242 / dev.110841 , PMID 25139854 , PMC 4199125 (free full text).