Integrin β-3

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Integrin beta-3
Integrin beta-3
according to PDB  1JV2
other names

Platelet membrane glycoprotein IIIa, GPIIIa

Existing structure data : PDB  1KUP , PDB  1KUZ

Properties of human protein
Mass / length primary structure 788 amino acids , 87,058 Da
Identifier
External IDs
Orthologue (human)
Entrez 1493
Ensemble ENSG00000163599
UniProt P05106
Refseq (mRNA) NM_001037631.2
Refseq (protein) NP_001032720.1
PubMed search 1493

Integrin β-3 (synonymous CD61 ) is a surface protein from the group of integrins .

properties

CD61 is a cell adhesion molecule and has several isoforms , of which A and C are formed in many tissues , e.g. B. A in osteoblasts and C in prostate and testes . CD61 forms integrin α V a heterodimeric receptor for cytotactin , fibronectin , laminin , matrix metalloproteinase-2 , osteopontin , Osteomodulin , prothrombin , thrombospondin , vitronectin , von Willebrand factor , NRG1 , FGF1 , IGF1 , fibrillin-1 and fractalkine (synonymous CX3CL1). It also forms a heterodimeric receptor with integrin alpha-IIb for fibronectin, fibrinogen , plasminogen , prothrombin, thrombospondin and vitronectin. The RGD sequence or HHLGGGAKQAGDV (in the gamma chain of the fibrinogen) is bound. The blood clotting is initiated by the binding of the fibrinogen . It is also involved in angiogenesis , which is why it is being studied for the treatment of tumors . PLA2G2A binds to a different binding site and modulates the affinity for the ligand of the receptor function. CD61 is glycosylated and phosphorylated . CD61 also binds PTK2 , ITGB3BP , TLN1 and CIB1 .

The heterodimer of integrin α-V and β-3 is the cellular receptor for the cytomegalovirus (HHV-5), HHV-8 , the coxsackievirus A9, the hantavirus , the human metapneumovirus , the human parechovirus 1 and the West Nile virus . When infected with HIV , the binding of the Tat protein to the heterodimer α-V / β-3 increases angiogenesis in Kaposi's sarcoma .

Web links

Individual evidence

  1. ↑ F. Danhier, A. Le Breton, V. Préat: RGD-based strategies to target alpha (v) beta (3) integrin in cancer therapy and diagnosis. In: Molecular pharmaceutics. Volume 9, Number 11, November 2012, pp. 2961-2973, doi : 10.1021 / mp3002733 , PMID 22967287 .
  2. ↑ BP Eliceiri, XS Puente, JD Hood, DG Stupack, DD Schlaepfer, XZ Huang, D. Sheppard, DA Cheresh: Src-mediated coupling of focal adhesion kinase to integrin alpha (v) beta5 in vascular endothelial growth factor signaling. In: Journal of Cell Biology . Volume 157, number 1, April 2002, pp. 149-160, doi : 10.1083 / jcb.200109079 , PMID 11927607 , PMC 2173263 (free full text).
  3. ↑ J. Chung, AG Gao, WA Frazier: Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. In: The Journal of biological chemistry. Volume 272, Number 23, June 1997, pp. 14740-14746, PMID 9169439 .
  4. ↑ TT Fujimoto, S. Katsutani, T. Shimomura, K. Fujimura: Novel alternatively spliced ​​form of beta (3) -endonexin. In: Thrombosis research. Volume 105, Number 1, January 2002, pp. 63-70, PMID 11864709 .
  5. ^ SJ Shattil, T. O'Toole, M. Eigenhaler, V. Thon, M. Williams, BM Babior, MH Ginsberg: Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. In: Journal of Cell Biology . Volume 131, Number 3, November 1995, pp. 807-816, PMID 7593198 , PMC 2120613 (free full text).
  6. ↑ S. Patil, A. Jedsadayanmata, JD Wencel-Drake, W. Wang, I. Knezevic, SC Lam: Identification of a talin-integrin binding site in the beta (3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta (3) cytoplasmic tail. In: The Journal of biological chemistry. Volume 274, Number 40, October 1999, pp. 28575-28583, PMID 10497223 .
  7. ↑ DA Calderwood, B. Yan, JM de Pereda, BG Alvarez, Y. Fujioka, RC Liddington, MH Ginsberg: The phosphotyrosine binding-like domain of talin activates integrins. In: The Journal of biological chemistry. Volume 277, Number 24, June 2002, pp. 21749-21758, doi : 10.1074 / jbc.M111996200 , PMID 11932255 .
  8. ↑ UP Naik, PM Patel, LV Parise: Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. In: The Journal of biological chemistry. Volume 272, Number 8, February 1997, pp. 4651-4654, PMID 9030514 .