CD48 antigen
| CD48 antigen | ||
|---|---|---|
| other names |
B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, leukocyte antigen MEM-102, SLAM family member 2, SLAMF2 |
|
| Properties of human protein | ||
| Mass / length primary structure | 243 amino acids , 27,683 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 5788 | |
| Ensemble | ENSG00000081237 | |
| UniProt | P09326 | |
| Refseq (mRNA) | NM_001267798.1 | |
| Refseq (protein) | NP_001254727.1 | |
| PubMed search |
5788
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The CD48 antigen is a surface protein from the group of cell adhesion molecules .
properties
CD48 binds CD2 and 2B4 and is a costimulator . It is glycosylated and has a GPI anchor .
Mutations in the CD48 gene can lead to a disease characterized by chronically recurring attacks of inflammation.
Web links
Individual evidence
- ↑ M. Elishmereni, F. Levi-Schaffer: CD48: A co-stimulatory receptor of immunity. In: The international journal of biochemistry & cell biology. Volume 43, number 1, January 2011, pp. 25-28, doi : 10.1016 / j.biocel.2010.09.001 , PMID 20833258 .
- ↑ Benjamin Volkmer, Raquel Planas, Emanuel Gossweiler, Anna Lünemann, Lennart Opitz, Andrea Mauracher, Ursina Nüesch, Tenzin Gayden, Daniela Kaiser, Barbara Drexel, Claudia Dumrese, Nada Jabado, Stefano Vavassori, Jana Pachlopnik Schmid: Recurrent inflammatory disease caused by a heterozygous mutation in CD48 . In: Journal of Allergy and Clinical Immunology . tape 144 , no. 5 , November 2019, p. 1441–1445.e17 , doi : 10.1016 / j.jaci.2019.07.038 ( elsevier.com [accessed July 8, 2020]).