CD53
| Leukocyte surface antigen CD53 | ||
|---|---|---|
| other names |
Cell surface glycoprotein CD53, Tetraspanin-25, Tspan-25, Ox-44 |
|
| Properties of human protein | ||
| Mass / length primary structure | 219 amino acids , 24,341 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue | ||
| human | mouse | |
| Entrez | 963 | 12508 |
| Ensemble | ENSG00000143119 | ENSMUSG00000040747 |
| UniProt | P19397 | Q61451 |
| Refseq (mRNA) | NM_000560.3 | |
| Refseq (protein) | NP_000551.1 | |
| Gene locus | ||
| PubMed search | 963 |
12508
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Tetraspanin-25 (synonymous CD53 ) is a surface protein from the group of tetraspanins .
properties
Like CD9 , CD63 and CD81 , tetraspanin-25 belongs to the group of tetraspanins, which are characterized by four hydrophobic protein domains . It is made by B cells , monocytes , macrophages , neutrophils, and simply CD4 or CD8 positive T cells and peripheral T cells. It is also produced by NK cells , where it inhibits the immune response of the NK cells. Tetraspanin-25 is glycosylated . It forms homomultimers of less than ten tetraspanin-25. Tetraspanin-25 binds to MT1-MMP .
The gene expression of tetraspanin-25 is reciprocal to the viral load in untreated HIV- infected people.
literature
- Y. Hu, G. Wu, M. Rusch, L. Lukes, KH Buetow, J. Zhang, KW Hunter: Integrated cross-species transcriptional network analysis of metastatic susceptibility. In: Proceedings of the National Academy of Sciences . Volume 109, Number 8, February 2012, pp. 3184-3189, doi : 10.1073 / pnas.1117872109 , PMID 22308418 , PMC 3286991 (free full text).
Web links
Individual evidence
- ↑ a b c E. Tippett, PU Cameron, M. Marsh, SM Crowe: Characterization of tetraspanins CD9, CD53, CD63, and CD81 in monocytes and macrophages in HIV-1 infection. In: Journal of leukocyte biology. Volume 93, Number 6, June 2013, pp. 913-920, doi : 10.1189 / jlb.0812391 , PMID 23570947 .
- ^ I. Todros-Dawda, L. Kveberg, JT Vaage, M. Inngjerdingen: The tetraspanin CD53 modulates responses from activating NK cell receptors, promoting LFA-1 activation and dampening NK cell effector functions. In: PloS one. Volume 9, number 5, 2014, p. E97844, doi : 10.1371 / journal.pone.0097844 , PMID 24832104 , PMC 4022634 (free full text).
- ↑ M. Zuidscherwoude, F. Göttfert, VM Dunlock, CG Figdor, G. van den Bogaart, AB van Spriel: The tetraspanin web revisited by super-resolution microscopy. In: Scientific reports. Volume 5, July 2015, p. 12201, doi : 10.1038 / srep12201 , PMID 26183063 , PMC 4505338 (free full text).
- ↑ HM Schröder, SC Hoffmann, M. Hecker, T. Korff, T. Ludwig: The tetraspanin network modulates MT1-MMP cell surface trafficking. In: The international journal of biochemistry & cell biology. Volume 45, number 6, June 2013, pp. 1133-1144, doi : 10.1016 / j.biocel.2013.02.020 , PMID 23500527 .