B lymphocyte antigen CD20

B-lymphocyte antigen CD20
	according to PDB 1S8B
other names	B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, membrane-spanning 4-domains subfamily A member 1
	Existing structure data : PDB 2OSL , PDB 3BKY
Properties of human protein
Mass / length primary structure	297 amino acids , 33,077 Da
Identifier
External IDs	GeneCards : MS4A1 ; UniProt : P11836 ;

B-lymphocyte antigen CD20 is a surface protein on the cell surface of B cells . It is phosphorylated and palmitoylated . CD20, which is also known as MS4A1 as a member of the MS4A family, is characterized by four conserved transmembrane domains that are flanked by N- and C-terminal cytoplasmic domains. CD20 is involved in the humoral immune response . It binds to MHCII and regulates the activation of the B cell receptor . Rituximab binds to CD20, as does ocrelizumab .

Web links

MeSH B lymphocyte antigen CD20

Individual evidence

↑ TF Tedder, M. Streuli, SF Schlossman, H. Saito: Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. In: Proceedings of the National Academy of Sciences . Volume 85, Number 1, January 1988, pp. 208-212, PMID 2448768 , PMC 279513 (free full text).
↑ MS Cragg, CA Walshe, AO Ivanov, MJ Glennie: The biology of CD20 and its potential as a target for mAb therapy. In: Current directions in autoimmunity. Volume 8, 2005, pp. 140-174, doi : 10.1159 / 000082102 , PMID 15564720 .

[1] TF Tedder, M. Streuli, SF Schlossman, H. Saito: Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. In: Proceedings of the National Academy of Sciences . Volume 85, Number 1, January 1988, pp. 208-212, PMID 2448768 , PMC 279513 (free full text).

[2] MS Cragg, CA Walshe, AO Ivanov, MJ Glennie: The biology of CD20 and its potential as a target for mAb therapy. In: Current directions in autoimmunity. Volume 8, 2005, pp. 140-174, doi : 10.1159 / 000082102 , PMID 15564720 .