CD49a

Integrin alpha-1
	according to PDB 1CK4 , in two views
other names	CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, CD49a
	Existing structure data : PDB 1PT6 , PDB 1QC5 , PDB 1QCY
Properties of human protein
Mass / length primary structure	1,179 amino acids , 130,848 Da
Identifier
External IDs	GeneCards : ITGA1 ; OMIM : 192968 ; UniProt : P56199 ;
	Orthologue

Integrin α-1 (synonymous CD49a ) is a surface protein from the group of integrins .

properties

Integrin α-1 is a cell adhesion molecule . Together with integrin beta-1, it forms a heterodimeric receptor for laminin and collagen . It binds to the amino acid sequence GlyPheHypGlyGluArg in collagen. It inhibits the activity of the EGF receptor . Integrin α-1 is glycosylated . It is expressed in mesenchymal cells , immune cells and some epithelial cells. It is involved in the composition of the extracellular matrix and in cell division and survival signals .

Integrin alpha-1

according to PDB 1CK4 , in two views
other names	CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, CD49a
Existing structure data : PDB 1PT6 , PDB 1QC5 , PDB 1QCY
Properties of human protein
Mass / length primary structure	1,179 amino acids , 130,848 Da
Identifier
External IDs	GeneCards : ITGA1 OMIM : 192968 UniProt : P56199
Orthologue
	human	House mouse
Entrez	3672	109700
Ensemble	ENSG00000213949	ENSMUSG00000042284
UniProt	P56199	Q3V3R4
Refseq (mRNA)	NM_181501.1	NM_001033228
Refseq (protein)	NP_852478.1	NP_001028400.2
Gene locus	Chr 5: 52.79 - 52.96 Mb	Chr 13: 114.96 - 115.1 Mb
PubMed search	3672	109700