CD1e
| T-cell surface glycoprotein CD1e, membrane-associated | ||
|---|---|---|
| other names |
R2G1 |
|
| Properties of human protein | ||
| Mass / length primary structure | 388 amino acids , 43,626 Da | |
| Identifier | ||
| External IDs | ||
T-cell surface glycoprotein CD1e, membrane-associated is a surface protein .
properties
It is among others in cortical thymocytes , Langerhans cells , dendritic cells , in some T cell leukemias formed. CD1E modulated in the course of the adaptive immune response , the antigen presentation of diacylated lipid -, lipopeptide - and glycolipid - antigens (including phosphatidylinositols and Sulfoglykolipide ) by the other CD1 variants compared to the T-cell receptors . The membrane-bound form of CD1e is inactive. In addition to lipids, it also binds to beta-2 microglobulin . CD1 is glycosylated and has disulfide bridges .
Web links
Individual evidence
- ↑ F. Facciotti, M. Cavallari, C. Angénieux, LF Garcia-Alles, F. Signorino-Gelo, L. Angman, M. Gilleron, J. Prandi, G. Puzo, L. Panza, C. Xia, Wang PG , P. Dellabona, G. Casorati, SA Porcelli, H. de la Salle, L. Mori, G. De Libero: Fine tuning by human CD1e of lipid-specific immune responses. In: Proceedings of the National Academy of Sciences . Volume 108, number 34, August 2011, pp. 14228-14233, doi : 10.1073 / pnas.1108809108 , PMID 21844346 , PMC 3161585 (free full text).