CD49c

Integrin alpha-3
other names	CD49 antigen-like family member C, FRP-2, galactoprotein B3, GAPB3, very late (activation) antigen 3, VLA-3, very common antigen 2, VCA-2, extracellular matrix receptor 1, ECMR1, galactoprotein b3, GAPB3
Properties of human protein
Mass / length primary structure	1,051 amino acids , 116,612 Da
Identifier
External IDs	GeneCards : ITGA3 ; OMIM : 605025 ; UniProt : P26006 ;
	Orthologue (human)
Entrez	3675
Ensemble	ENSG00000005884
UniProt	P26006
Refseq (mRNA)	NM_002204.3
Refseq (protein)	NP_002195.1
PubMed search	3675

Integrin α-3 (synonym CD49c ) is a surface protein from the group of integrins .

properties

Integrin α-3 is a cell adhesion molecule . The isoform 1 is in many tissues formed, the isoform 2 in the brain and heart. In the brain, both isoforms are only on cells of the smooth muscle of blood vessels formed, while in the heart of the isoform 1 mainly by smooth muscle cells and isoform 2 only by endothelial cells of the vein expressed will. Integrin α-3 forms with integrin beta-1 a heterodimeric receptor for fibronectin , laminin , collagen , epiligrin , thrombospondin and CSPG4 . It is glycosylated , palmitoylated and phosphorylated . Integrin α-3 is believed to be involved in the metastasis of tumors .

Mutations in integrin α-3 are involved in the development of epidermolysis bullosa .

Integrin α-3 binds to CD9 , FHL2 , LGALS8 , and TSPAN4 .

Web links

MeSH CD49c

Individual evidence

↑ JM Pawelek, AK Chakraborty: The cancer cell-leukocyte fusion theory of metastasis. In: Advances in Cancer Research . Volume 101, 2008, pp. 397-444, doi : 10.1016 / S0065-230X (08) 00410-7 , PMID 19055949 .
^ JA McGrath: Recently Identified Forms of Epidermolysis Bullosa. In: Annals of dermatology. Volume 27, number 6, December 2015, pp. 658-666, doi : 10.5021 / ad.2015.27.6.658 , PMID 26719633 , PMC 4695416 (free full text).
↑ Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S: CD9 is expressed on human endometrial epithelial cells in association with integrins alpha (6), alpha (3) and beta (1) . In: Mol. Hum. Reprod. . 6, No. 3, March 2000, pp. 252-7. doi : 10.1093 / molehr / 6.3.252 . PMID 10694273 .
↑ Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S: CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5 . In: Mol. Hum. Reprod. . 5, No. 2, February 1999, pp. 162-7. doi : 10.1093 / molehr / 5.2.162 . PMID 10065872 .
↑ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M: The LIM-only protein DRAL / FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes . In: J. Biol. Chem. . 275, No. 43, October 2000, pp. 33669-78. doi : 10.1074 / jbc.M002519200 . PMID 10906324 .
↑ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y: Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis . In: J. Cell. Sci. . 113, No. 13, July 2000, pp. 2385-97. PMID 10852818 .
↑ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME: NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins . In: J. Biol. Chem. . 272, No. 46, November 1997, pp. 29181-9. doi : 10.1074 / jbc.272.46.29181 . PMID 9360996 .

[1] JM Pawelek, AK Chakraborty: The cancer cell-leukocyte fusion theory of metastasis. In: Advances in Cancer Research . Volume 101, 2008, pp. 397-444, doi : 10.1016 / S0065-230X (08) 00410-7 , PMID 19055949 .

[2] JA McGrath: Recently Identified Forms of Epidermolysis Bullosa. In: Annals of dermatology. Volume 27, number 6, December 2015, pp. 658-666, doi : 10.5021 / ad.2015.27.6.658 , PMID 26719633 , PMC 4695416 (free full text).

[pmid10694273-3] Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S: CD9 is expressed on human endometrial epithelial cells in association with integrins alpha (6), alpha (3) and beta (1) . In: Mol. Hum. Reprod. . 6, No. 3, March 2000, pp. 252-7. doi : 10.1093 / molehr / 6.3.252 . PMID 10694273 .

[pmid10065872-4] Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S: CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5 . In: Mol. Hum. Reprod. . 5, No. 2, February 1999, pp. 162-7. doi : 10.1093 / molehr / 5.2.162 . PMID 10065872 .

[pmid10906324-5] Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M: The LIM-only protein DRAL / FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes . In: J. Biol. Chem. . 275, No. 43, October 2000, pp. 33669-78. doi : 10.1074 / jbc.M002519200 . PMID 10906324 .

[pmid10852818-6] Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y: Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis . In: J. Cell. Sci. . 113, No. 13, July 2000, pp. 2385-97. PMID 10852818 .

[pmid9360996-7] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME: NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins . In: J. Biol. Chem. . 272, No. 46, November 1997, pp. 29181-9. doi : 10.1074 / jbc.272.46.29181 . PMID 9360996 .