Intercellular cell adhesion molecule 1

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Intercellular adhesion molecule 1
other names

Major group rhinovirus receptor, CD_antigen: CD54, ICAM-1

Existing structure data : PDB  1D3E , PDB  1D3I , PDB  1D3L

Properties of human protein
Mass / length primary structure 532 amino acids , 57,825 Da
Identifier
External IDs
Orthologue
human mouse
Entrez 3383 15894
Ensemble ENSG00000090339 ENSMUSG00000037405
UniProt P05362 P13597
Refseq (mRNA) NM_000201.2
Refseq (protein) NP_000192.2
Gene locus
PubMed search 3383 15894

Intercellular adhesion molecule 1 (synonym ICAM-1 , CD54 ) is a surface protein from the group of integrins .

properties

ICAM proteins are cell adhesion molecules that bind to LFA-1 (a complex of integrin alpha-L and integrin beta-2 , synonymous CD11a / CD18 ) as well as integrin alpha-M and integrin beta-2 ( CD11b / CD18). During leukodiapedesis , binding to ICAM-1 leads to the assembly of invaginations of the apical cell membrane of endothelial cells . It is glycosylated and phosphorylated . The expression of ICAM-1 is interleukin-1 and interferon-gamma enhanced. In an atherosclerosis elevated levels of ICAM-1 occur.

ICAM-1 is the cellular receptor of most rhinovirus strains ( capsid protein A or B) and of the coxsackievirus (capsid protein A21). In patients with Kaposi's sarcoma , ICAM-1 is broken down in the ubiquitin-proteasome system by the viral E3 ubiquitin ligase MIR-2 of HHV-8 for purposes of immune evasion .

A mutation in ICAM1 (K469E) leads to an increased risk of coronary artery disease .

Web links

Individual evidence

  1. ^ ML Dustin, R. Rothlein, AK Bhan, CA Dinarello, TA Springer: Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. In: Journal of Immunology. Volume 186, Number 9, May 2011, pp. 5024-5033, PMID 21505214 .
  2. ↑ C. Lawson, S. Wolf: ICAM-1 signaling in endothelial cells. In: Pharmacological reports: PR. Volume 61, Number 1, 2009 Jan-Feb, pp. 22-32, PMID 19307690 .
  3. ^ D. Li, C. Qu, P. Dong: The ICAM-1 K469E polymorphism is associated with the risk of coronary artery disease: a meta-analysis. In: Coronary artery disease. Volume 25, Number 8, December 2014, pp. 665-670, doi : 10.1097 / MCA.0000000000000136 , PMID 25025994 .