Integrin β-2

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Integrin beta-2
Integrin beta-2
according to PDB  1L3Y
other names

Cell surface adhesion glycoproteins LFA-1 / CR3 / p150.95 subunit beta, complement receptor C3 subunit beta, CD18

Existing structure data : PDB  1JX3 , PDB  1YUK

Properties of human protein
Mass / length primary structure 769 amino acids , 84,782 Da
Identifier
External IDs

Integrin β-2 (synonym CD18 ) is a surface protein from the group of integrins .

properties

CD18 binds to integrin α-D , integrin α-L , integrin α-M or integrin α-X and thus forms various heterodimers . It is made by leukocytes . As a heterodimer with integrin α-L (synonym CD11a) it is referred to as LFA-1 and binds to ICAM 1 to 4. Bound to ICAM3, α-L / β-2 induces phagocytosis of apoptotic neutrophils by macrophages . As a heterodimer with integrin α-M (synonym CD11b , together called macrophage-1 antigen ) or integrin α-X (synonym CD11c ), receptors for iC3b of the complement system and for fibrinogen arise . In the case of α-M / β-2, there is a binding to the peptides P1 and P2 of the γ chain of fibrinogen. α-M / β-2 is also a receptor for factor X . In the case of α-X / β-2, there is a binding to the sequence GPR in the α chain of the fibrinogen. α-X / β-2 is a receptor for ICAM 3 and VCAM1 . CD18 is involved in the cytotoxicity of NK cells . It is involved in cell adhesion and leukodiapedesis of leukocytes. CD18 is glycosylated and phosphorylated .

Integrin β-2 binds to FHL2 , GNB2L1 , ICAM-1 and PSCD1 , among others .

Web links

Individual evidence

  1. ↑ E. Kristóf, G. Zahuczky, K. Katona, Z. Doró, .. Nagy, L. Fés & uu: Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. In: Apoptosis. Volume 18, Number 10, October 2013, pp. 1235-1251, doi : 10.1007 / s10495-013-0873-z , PMID 23775590 .
  2. ↑ DF Barber, M. Faure, EO Long: LFA-1 contributes an early signal for NK cell cytotoxicity. In: Journal of Immunology (Baltimore, Md.: 1950). Volume 173, Number 6, September 2004, pp. 3653-3659, PMID 15356110 .
  3. ↑ G. Ostermann, KS Weber, A. Zernecke, A. Schröder, C. Weber: JAM-1 is a ligand of the beta (2) integrin LFA-1 involved in transendothelial migration of leukocytes. In: Nature Immunology . Volume 3, Number 2, February 2002, pp. 151-158, doi : 10.1038 / ni755 , PMID 11812992 .
  4. ↑ J. Xu, XP Gao, R. Ramchandran, YY Zhao, SM Vogel, AB Malik: Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins. In: Nature Immunology . Volume 9, number 8, August 2008, pp. 880-886, doi : 10.1038 / ni.1628 , PMID 18587400 , PMC 2553242 (free full text).
  5. ↑ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M: The LIM-only protein DRAL / FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes . In: The Journal of Biological Chemistry . 275, No. 43, October 2000, pp. 33669-78. doi : 10.1074 / jbc.M002519200 . PMID 10906324 .
  6. ↑ Liliental J, Chang DD: Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit . In: The Journal of Biological Chemistry . 273, No. 4, January 1998, pp. 2379-83. doi : 10.1074 / jbc.273.4.2379 . PMID 9442085 .
  7. ↑ Kotovuori A, Pessa-Morikawa T, Kotovuori P, Nortamo P, Gahmberg CG: ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity . In: Journal of Immunology . 162, No. 11, June 1999, pp. 6613-20. PMID 10352278 .
  8. ^ Lu C, Takagi J, Springer TA: Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state . In: The Journal of Biological Chemistry . 276, No. 18, May 2001, pp. 14642-8. doi : 10.1074 / jbc.M100600200 . PMID 11279101 .
  9. ↑ Huang C, Springer TA: A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1) . In: The Journal of Biological Chemistry . 270, No. 32, August 1995, pp. 19008-16. doi : 10.1074 / jbc.270.32.19008 . PMID 7642561 .
  10. ^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B: The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins . In: The Journal of Biological Chemistry . 273, No. 42, October 1998, pp. 27459-66. doi : 10.1074 / jbc.273.42.27459 . PMID 9765275 .
  11. ↑ Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W: Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF- GEF function and interaction with LFA-1 . In: The EMBO Journal . 19, No. 11, June 2000, pp. 2525-36. doi : 10.1093 / emboj / 11/19/2525 . PMID 10835351 . PMC 212768 (free full text).