Integrin α-X
| Integrin alpha-X | ||
|---|---|---|
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| according to PDB 1N3Y | ||
| other names |
CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150 |
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| Properties of human protein | ||
| Mass / length primary structure | 1,163 amino acids , 127,829 Da | |
| Identifier | ||
| External IDs | ||
Integrin α-X (synonym CD11c) is a surface protein from the group of integrins .
properties
Integrin α-X binds to integrin β-2 (synonym CD18) and thus forms heterodimers . Together they form a receptor for fibrinogen by binding to its sequence GPR. It is also involved in cell contacts during inflammation . Integrin α-X is formed in monocytes , granulocytes and dendritic cells and is used for chemotaxis and cell adhesion . It's glycosylated .
Web links
Individual evidence
- ↑ BM Bradford, DP Sester, DA Hume, NA Mabbott: Defining the anatomical localization of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages. In: Immunobiology. Volume 216, Number 11, November 2011, pp. 1228-1237, doi: 10.1016 / j.imbio.2011.08.006 , PMID 21885153 .