Integrin α-L
| Integrin alpha-L | ||
|---|---|---|
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| according to PDB 1CQP | ||
| other names |
CD11a, CD11 antigen-like family member A, leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A |
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| Properties of human protein | ||
| Mass / length primary structure | 1,170 amino acids , 128,770 Da | |
| Identifier | ||
| External IDs | ||
Integrin α-L (synonym CD11a) is a surface protein .
properties
CD11a is a cell adhesion molecule and is produced in leukocytes . CD11a is glycosylated , phosphorylated and has disulfide bridges . It forms a heterodimer with integrin β-2 . It binds as a heterodimeric integrin alpha-L / beta-2 to ICAM1 , ICAM2 , ICAM3 and ICAM4 . It also binds F11R . It is involved in cell adhesion and leukodiapedesis of leukocytes. CD11a activates phagocytosis in macrophages. It binds calcium ions and is glycosylated , phosphorylated and has disulfide bridges. Efalizumab binds to CD11a.
Web links
Individual evidence
- ↑ G. Ostermann, KS Weber, A. Zernecke, A. Schröder, C. Weber: JAM-1 is a ligand of the beta (2) integrin LFA-1 involved in transendothelial migration of leukocytes. In: Nature Immunology . Volume 3, Number 2, February 2002, pp. 151-158, doi : 10.1038 / ni755 , PMID 11812992 .
- ↑ E. Kristóf, G. Zahuczky, K. Katona, Z. Doró, .. Nagy, L. Fés & uu: Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. In: Apoptosis. Volume 18, Number 10, October 2013, pp. 1235-1251, doi : 10.1007 / s10495-013-0873-z , PMID 23775590 .