Integrin α-M
| Integrin alpha-M | ||
|---|---|---|
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| according to PDB 1BHO , in 2 views | ||
| other names |
CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor |
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| Properties of human protein | ||
| Mass / length primary structure | 1,152 amino acids , 127,179 Da | |
| Identifier | ||
| External IDs | ||
Integrin α-M (synonym CD11b ) is a surface protein .
properties
CD11b is a cell adhesion molecule and is mainly formed in dendritic cells , monocytes , macrophages and granulocytes . The protein complex of integrin α-M and integrin β-2 is involved in cell adhesion and endocytosis of complement- bound particles by binding to the RGD peptide in C3b . The complex also binds to fibrinogen (P1 and P2 peptides of the gamma chain), factor X and ICAM1 . CD11b binds calcium ions, is glycosylated and has disulfide bridges .
Web links
Individual evidence
- ^ A. Iwasaki: The importance of CD11b + dendritic cells in CD4 + T cell activation in vivo: with help from interleukin 1. In: The Journal of experimental medicine. Volume 198, number 2, July 2003, pp. 185-190, doi : 10.1084 / jem.20030737 , PMID 12860934 , PMC 2194080 (free full text).