Ectonucleoside triphosphate diphosphohydrolase 1
| Ectonucleoside triphosphate diphosphohydrolase 1 | ||
|---|---|---|
| other names |
CD39, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Ectonucleoside triphosphate diphosphohydrolase 1 |
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| Properties of human protein | ||
| Mass / length primary structure | 510 amino acids , 57,965 Da | |
| Secondary to quaternary structure | Homodimer | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.6.1.5 | |
| Orthologue (human) | ||
| Entrez | 953 | |
| Ensemble | ENSG00000138185 | |
| UniProt | P49961 | |
| Refseq (mRNA) | NM_001098175.1 | |
| Refseq (protein) | NP_001091645.1 | |
| PubMed search |
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Ectonucleoside triphosphate diphosphohydrolase 1 (synonym CD39 ) is a surface protein from the group of ATPases .
properties
CD39 is mainly formed in activated lymphocytes and endothelial cells . The isoform 1 and isoform 3 come in the placenta and in the umbilical cord before, isoform 2, however, only in the placenta. It is involved in purinergic signal transduction through hydrolysis of adenosine triphosphate (ATP) to adenosine monophosphate (AMP) and two phosphates or from adenosine diphosphate to AMP and phosphate. It is glycosylated and palmitoylated . CD39 is a homodimer with disulfide bridge- linked subunits. A cofactor are divalent magnesium ions.
Web links
Individual evidence
- ↑ MC Takenaka, S. Robson, FJ Quintana: Regulation of the T Cell Response by CD39. In: Trends in immunology. Volume 37, Number 7, July 2016, pp. 427-439, doi : 10.1016 / j.it.2016.04.009 , PMID 27236363 .