Leukocyte antigen CD37
| Leukocyte antigen CD37 | ||
|---|---|---|
| other names |
Tetraspanin-26, Tspan-26, leukocyte antigen CD37 |
|
| Properties of human protein | ||
| Mass / length primary structure | 281 amino acids , 31,703 Da | |
| Identifier | ||
| External IDs | ||
Leukocyte antigen CD37 is a surface protein from the group of tetraspanins . It is mainly produced by B cells and to a lesser extent by other immune cells . CD37 is glycosylated . It is involved in the Akt signaling pathway and in the binding of integrin α-4 to integrin β1 . The antibodies otlertuzumab and telulomab bind to CD37 and are being studied for the treatment of B-cell lymphoma .
Web links
Individual evidence
- ↑ a b K. A. Beckwith, JC Byrd, N. Muthusamy: Tetraspanins as therapeutic targets in hematological malignancy: a concise review. In: Frontiers in physiology. Volume 6, 2015, p. 91, doi : 10.3389 / fphys.2015.00091 , PMID 25852576 , PMC 4369647 (free full text).
- ↑ T. Robak, P. Robak: Anti-CD37 antibodies for chronic lymphocytic leukemia. In: Expert opinion on biological therapy. Volume 14, number 5, May 2014, pp. 651-661, doi : 10.1517 / 14712598.2014.890182 , PMID 24555705 .