CD83

from Wikipedia, the free encyclopedia
CD83 antigen
other names

B-cell activation protein, Cell surface protein HB15, CD83

Existing structure data : PDB  5MIX , PDB  5MJ0 , PDB  5MJ1

Properties of human protein
Mass / length primary structure 205 amino acids , 23,042 Da
Identifier
External IDs
Orthologue (human)
Entrez 9308
Ensemble ENSG00000112149
UniProt Q01151
Refseq (mRNA) NM_001040280.1
Refseq (protein) NP_001035370.1
PubMed search 9308

CD83 is a surface protein and participates in the regulation of the immune response .

properties

CD83 is of activated lymphocytes , dendritic cells and interdigitating reticulum cells formed. CD83 is glycosylated . The CD83 mRNA is exported from the nucleus to the cytosol via CRM1 . Two isoforms of CD83 are formed from this, an immunostimulating membrane-bound form and an immunosuppressive soluble form. The soluble form has structural similarities to B7-1 , B7-2 and CD48 . CD83 is also involved in the maturation of B and T cells .

Web links

Individual evidence

  1. ^ A b c A. T. Prechtel, A. Steinkasserer: CD83: an update on functions and prospects of the maturation marker of dendritic cells. In: Archives of dermatological research. Volume 299, Number 2, May 2007, pp. 59-69, doi : 10.1007 / s00403-007-0743-z , PMID 17334966 (review).
  2. ↑ JM Horvatinovich, EW Grogan, M. Norris, A. Steinkasserer, H. Lemos, AL Mellor, IY Tcherepanova, CA Nicolette, MA DeBenedette: Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4 / MD-2 Complex on CD14 ( +) Monocytes. In: Journal of Immunology. Volume 198, number 6, March 2017, pp. 2286-2301, doi : 10.4049 / jimmunol.1600802 , PMID 28193829 , PMC 5337811 (free full text).
  3. ↑ CS Heilingloh, S. Klingl, C. Egerer-Sieber, B. Schmid, S. Weiler, P. Mühl-Zürbes, J. Hofmann, JD Stump, H. Sticht, M. Kummer, A. Steinkasserer, YA Muller: Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83. In: Journal of molecular biology. Volume 429, number 8, April 2017, pp. 1227-1243, doi : 10.1016 / j.jmb.2017.03.009 , PMID 28315353 .
  4. ↑ M. Breloer, B. Fleischer: CD83 regulates lymphocyte maturation, activation and homeostasis. In: Trends in immunology. Volume 29, Number 4, April 2008, pp. 186-194, doi : 10.1016 / j.it.2008.01.009 , PMID 18329338 .