CD6
| T-cell differentiation antigen CD6 | ||
|---|---|---|
| other names |
T12, TP120 |
|
| Properties of human protein | ||
| Mass / length primary structure | 668 amino acids , 71,801 Da | |
| Identifier | ||
| External IDs | ||
T-cell differentiation antigen CD6 is a surface protein from the group of cell adhesion molecules .
properties
CD6 is produced by thymocytes , NK cells and B1 cells . It is a cell adhesion molecule that enhances the T cell response . CD6 binds to lipopolysaccharide from Gram-negative bacteria and lipoteichoic acids from Gram-positive bacteria and then activates the MAPK signaling pathway. CD6 is glycosylated , phosphorylated and has disulfide bridges .
Web links
Individual evidence
- ^ I. Gimferrer, M. Calvo, M. Mittelbrunn, M. Farnós, MR Sarrias, C. Enrich, J. Vives, F. Sánchez-Madrid, F. Lozano: Relevance of CD6-mediated interactions in T cell activation and proliferation . In: Journal of Immunology (Baltimore, Md.: 1950). Volume 173, Number 4, August 2004, pp. 2262-2270, PMID 15294938 .
- ↑ MR Sarrias, M. Farnós, R. Mota, F. Sánchez-Barbero, A. Ibáñez, I. Gimferrer, J. Vera, R. Fenutría, C. Casals, J. Yélamos, F. Lozano: CD6 binds to pathogen Associated molecular patterns and protects from LPS-induced septic shock. In: Proceedings of the National Academy of Sciences . Volume 104, number 28, July 2007, pp. 11724-11729, doi : 10.1073 / pnas.0702815104 , PMID 17601777 , PMC 1913855 (free full text).