Low Density Lipoprotein Receptor-related Protein 1
| Prolow-density lipoprotein receptor-related protein 1 | ||
|---|---|---|
| other names |
Alpha-2 macroglobulin receptor, CD91, LRP1 |
|
| Properties of human protein | ||
| Mass / length primary structure | 4,544 amino acids , 504,606 Da | |
| Secondary to quaternary structure | Heterodimer | |
| Identifier | ||
| External IDs | ||
| Occurrence | ||
| Parent taxon | Bilateria (bilateral animals) | |
| Orthologue | ||
| human | mouse | |
| Entrez | 4035 | 16971 |
| Ensemble | ENSG00000123384 | ENSMUSG00000040249 |
| UniProt | Q07954 | Q3U454 |
| Refseq (mRNA) | NM_002332 | NM_008512 |
| Refseq (protein) | NP_002323 | NP_032538 |
| Gene locus | Chr 12: 55.81 - 55.89 Mb | Chr 10: 126.94 - 127.02 Mb |
| PubMed search | 4035 |
16971
|
The Low Density Lipoprotein Receptor-related Protein 1 (LRP1) is a cellular membrane receptor of the LDL receptor family.
properties
CD91 is a dimer of an 85 kDa transmembrane fragment and a 515 kDa fragment that is non-covalently linked on the extracellular side. LRP1 is a multi-ligand receptor that was initially discovered as a transport receptor, but has now also been described as a signal receptor. Of the four domains of the protein, II and IV bind the majority of the ligands.
CD91 is mainly produced in the liver, brain and lungs. It serves as a receptor to initiate endocytosis of apoptotic cells. CD91 is essential for early embryonic development . It is also involved in regulating the composition of the cell membrane . It is involved in the absorption of chylomicron remnants, alpha-2-macroglobulin and complexes of plasminogen activators and their inhibitors from the blood plasma . It also binds complexes with serpins and heat shock proteins . CD91 is glycosylated and phosphorylated .
CD91 is also the cellular receptor for exotoxin A from Pseudomonas aeruginosa . CD91 is increasingly formed in monocytes of HIV- infected long-term non-progressors .
Web links
swell
- ↑ J. Herz, DK Strcikland: LRP: a multifunctional scavenger and signaling receptor. In: J Clin Invest. 108 (6), 2001, pp. 779-784. PMID 11560943
- ↑ Hye Suk Kang, JinKyoung Kim, Heon-Jin Lee, Byoung-Mog Kwon, Dong-Ki Lee: LRP1-dependent pepsin clearance induced by 2′-hydroxycinnamaldehyde attenuates breast cancer cell invasion . In: The International Journal of Biochemistry & Cell Biology . tape 53 , August 2014, ISSN 1357-2725 , p. 15–23 , doi : 10.1016 / j.biocel.2014.04.021 ( elsevier.com [accessed on May 11, 2018]).
- ↑ U. Beisiegel, W. Weber, G. Ihrke, J. Herz, KK Stanley: The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. In: Nature. 341 (6238), 1989, pp. 162-164. PMID 2779654
- ↑ a b L. F. Congote: Serpin A1 and CD91 as host instruments against HIV-1 infection: are extracellular antiviral peptides acting as intracellular messengers? In: Virus research. Volume 125, Number 2, May 2007, pp. 119-134, doi : 10.1016 / j.virusres.2006.12.018 , PMID 17258834 .
- ↑ J. Stebbing, P. Savage, S. Patterson, B. Gazzard: All for CD91 and CD91 for all. In: The Journal of antimicrobial chemotherapy. Volume 53, Number 1, January 2004, pp. 1-3, doi : 10.1093 / jac / dkh010 , PMID 14657092 .