CD84

SLAM family member 5
other names	Cell surface antigen MAX. 3, Hly9-beta, leukocyte differentiation antigen CD84, signaling lymphocytic activation molecule 5
	Existing structural data : PDB 2PKD
Properties of human protein
Mass / length primary structure	345 amino acids , 38,782 Da
Identifier
External IDs	GeneCards : CD84 ; OMIM : 604513 ; UniProt : Q9UIB8 ;
	Orthologue (human)
Entrez	8832
Ensemble	ENSG00000066294
UniProt	Q9UIB8
Refseq (mRNA)	NM_001184879.1
Refseq (protein)	NP_001171808.1
PubMed search	8832

CD84 (synonym SLAM family member 5 ) is a surface protein from the group of SLAM receptors .

properties

CD84 is produced by various immune cells in lymph nodes and the spleen . It binds other CD84 molecules on neighboring cells, thereby increasing the production of interferon-gamma in activated T cells . SLAM receptors ( signaling lymphocytic activation molecule ) regulate the activation and differentiation of various immune cells. The activity is also regulated by the cellular adapter proteins SH2D1A / SAP and / or SH2D1B / EAT-2 . CD84 is involved in the cell proliferation of activated T cells. CD84 is necessary for longer cell contact between T and B cells . CD84 inhibits the activation of mast cells . CD84 is glycosylated and phosphorylated .

CD84 is believed to be involved in the development of lupus erythematosus and CLL .

Web links

MeSH CD84

Individual evidence

↑ Q. Yan, VN Malashkevich, A. Fedorov, E. Fedorov, E. Cao, JW Lary, JL Cole, SG Nathenson, SC Almo: Structure of CD84 Provides insight into SLAM family function. In: Proceedings of the National Academy of Sciences . Volume 104, number 25, June 2007, pp. 10583-10588, doi : 10.1073 / pnas.0703893104 , PMID 17563375 , PMC 1965556 (free full text).
↑ D. Álvarez-Errico, I. Oliver-Vila, E. Ainsua-Enrich, AM Gilfillan, C. Picado, J. Sayós, M. Martín: CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells. In: Journal of Immunology. Volume 187, number 11, December 2011, pp. 5577-5586, doi : 10.4049 / jimmunol.1101626 , PMID 22068234 , PMC 3233232 (free full text).
↑ EB Wong, C. Soni, AY Chan, PP Domeier ,. Shwetank, T. Abraham, N. Limaye, TN Khan, MJ Elias, SB Chodisetti, EK Wakeland, ZS Ra: B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. In: Journal of Immunology. Volume 194, number 9, May 2015, pp. 4130-4143, doi : 10.4049 / jimmunol.1403023 , PMID 25801429 , PMC 4402266 (free full text).
↑ I. Binsky-Ehrenreich, A. Marom, MC Sobotta, L. Shvidel, A. Berrebi, I. Hazan-Halevy, S. Kay, A. Aloshin, I. Sagi, DM Goldberg, L. Leng, R. Bucala , Y. Herishanu, M. Haran, I. Shachar: CD84 is a survival receptor for CLL cells. In: Oncogene. Volume 33, number 8, February 2014, pp. 1006-1016, doi : 10.1038 / onc.2013.31 , PMID 23435417 , PMC 3796123 (free full text).

[1] Q. Yan, VN Malashkevich, A. Fedorov, E. Fedorov, E. Cao, JW Lary, JL Cole, SG Nathenson, SC Almo: Structure of CD84 Provides insight into SLAM family function. In: Proceedings of the National Academy of Sciences . Volume 104, number 25, June 2007, pp. 10583-10588, doi : 10.1073 / pnas.0703893104 , PMID 17563375 , PMC 1965556 (free full text).

[2] D. Álvarez-Errico, I. Oliver-Vila, E. Ainsua-Enrich, AM Gilfillan, C. Picado, J. Sayós, M. Martín: CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells. In: Journal of Immunology. Volume 187, number 11, December 2011, pp. 5577-5586, doi : 10.4049 / jimmunol.1101626 , PMID 22068234 , PMC 3233232 (free full text).

[3] EB Wong, C. Soni, AY Chan, PP Domeier ,. Shwetank, T. Abraham, N. Limaye, TN Khan, MJ Elias, SB Chodisetti, EK Wakeland, ZS Ra: B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. In: Journal of Immunology. Volume 194, number 9, May 2015, pp. 4130-4143, doi : 10.4049 / jimmunol.1403023 , PMID 25801429 , PMC 4402266 (free full text).

[4] I. Binsky-Ehrenreich, A. Marom, MC Sobotta, L. Shvidel, A. Berrebi, I. Hazan-Halevy, S. Kay, A. Aloshin, I. Sagi, DM Goldberg, L. Leng, R. Bucala , Y. Herishanu, M. Haran, I. Shachar: CD84 is a survival receptor for CLL cells. In: Oncogene. Volume 33, number 8, February 2014, pp. 1006-1016, doi : 10.1038 / onc.2013.31 , PMID 23435417 , PMC 3796123 (free full text).