ICAM-3
| Intercellular adhesion molecule 3 | ||
|---|---|---|
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| according to PDB 1T0P | ||
| other names |
CDw50, ICAM-R, CD_antigen: CD50 |
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| Properties of human protein | ||
| Mass / length primary structure | 547 amino acids , 59,541 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 3385 | |
| Ensemble | ENSG00000076662 | |
| UniProt | P32942 | |
| Refseq (mRNA) | NM_001320605.1 | |
| Refseq (protein) | NP_001307534.1 | |
| PubMed search |
3385
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The intercellular adhesion molecule 3 (engl. Adhesion molecule intercellular 3 ; ICAM-3, CD50) is a surface protein from the group of cell adhesion molecules .
properties
ICAM-3 is produced by leukocytes . It binds to LFA-1 (complex of integrin alpha-L and integrin beta-2 ) and to the complex of integrin alpha-D and integrin beta-2. The binding of ICAM-3 to integrin alpha-D and integrin beta-2 is involved in the phagocytosis of apoptotic neutrophils by macrophages . ICAM-3 is glycosylated and phosphorylated .
Web links
Individual evidence
- ↑ E. Kristóf, G. Zahuczky, K. Katona, Z. Doró, É. Nagy, L. Fésüs Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. In: Apoptosis. Volume 18, Number 10, October 2013, pp. 1235-1251, doi : 10.1007 / s10495-013-0873-z , PMID 23775590 .