5'-nucleotidase
| 5'-nucleotidase | ||
|---|---|---|
| other names |
Ecto-5'-nucleotidase, CD73 antigen |
|
| Properties of human protein | ||
| Mass / length primary structure | 574 amino acids , 63,368 Da | |
| Secondary to quaternary structure | Homodimer | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.1.3.5 | |
| Orthologue (human) | ||
| Entrez | 4907 | |
| Ensemble | ENSG00000135318 | |
| UniProt | P21589 | |
| Refseq (mRNA) | NM_001204813.1 | |
| Refseq (protein) | NP_001191742.1 | |
| Gene locus | Chr 6: 85.45 - 85.5 Mb | |
| PubMed search |
4907
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The 5'-nucleotidase is an enzyme from the group of nucleotidases and a surface protein .
properties
The 5'-nucleotidase hydrolyzes nucleotides outside of cells to form nucleosides , which can then be transported through the cell membrane into the interior of the cell. Among other things , it hydrolyzes AMP , NAD and NMN to the respective nucleosides. As cofactor are Zn 2+ bound ions. The 5'-nucleotidase is glycosylated and has a GPI anchor . Adenosine is formed through the hydrolysis of AMP , which binds to the adenosine receptor and leads to vasodilation , anti-inflammatory and anticoagulant effects, and inhibition of adrenergic effects.
The 5'-nucleotidase is involved in toxin- induced fibrosis of the liver . It is a cell type marker for the development of lymphocytes .
Gene defects in 5'-nucleotidase lead to calcium deposits in joints and arteries ( calcification of joints and arteries , CALJA).
Web links
Individual evidence
- ↑ P. Zukowska, B. Kutryb-Zajac, M. Toczek, RT Smolenski, EM Slominska: The role of ecto-5'-nucleotidase in endothelial dysfunction and vascular pathologies. In: Pharmacological reports: PR. Volume 67, number 4, August 2015, pp. 675-681, doi : 10.1016 / j.pharep.2015.05.002 , PMID 26321267 .
- ↑ Z. Peng, P. Fernandez, T. Wilder, H. Yee, L. Chiriboga, ES Chan, BN Cronstein: Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. In: Nucleosides, nucleotides & nucleic acids. Volume 27, Number 6, June 2008, pp. 821-824, doi : 10.1080 / 15257770802146403 , PMID 18600546 .
- ^ C. St Hilaire, SG Ziegler, TC Markello, A. Brusco, C. Groden, F. Gill, H. Carlson-Donohoe, RJ Lederman, MY Chen, D. Yang, MP Siegenthaler, C. Arduino, C. Mancini , B. Freudenthal, HC Stanescu, AA Zdebik, RK Chaganti, RL Nussbaum, R. Kleta, WA Gahl, M. Boehm: NT5E mutations and arterial calcifications. In: The New England Journal of Medicine . Volume 364, Number 5, February 2011, pp. 432-442, doi : 10.1056 / NEJMoa0912923 , PMID 21288095 , PMC 3049958 (free full text).