CD3 receptor
The so-called CD3 antigen , also known as CD3 receptor , is a protein complex that belongs to the cluster of differentiation and is made up of four different polypeptide chains . In mammals, it consists of a gamma chain, a delta chain and two epsilon chains. Together with the T cell receptor (TCR) and the so-called zeta chain, they form the TCR-CD3 complex, which is used to activate T lymphocytes .
The CD3 chains are transmembrane proteins that belong to the immunoglobulin superfamily . The transmembrane domain of the CD3 chains is negatively charged and therefore allows binding to the TCR. The intracellular portion of the CD3 chains contains highly conserved peptide segments, so-called immunoreceptor tyrosine-based activation motif (ITAM for short), which is part of the intracellular signal path associated with the CD3-TCR. After phosphorylation of the intracellular portion of CD3, the so-called ZAP70 protein binds to the receptor, which sets the signal cascade in motion.
See also
literature
- Cellular and Molecular Immunology (5th Ed.) Abbas AK, and Lichtman, Editor: Saunders, Philadelphia, 2003.