CD1d
| Antigen-presenting glycoprotein CD1d | ||
|---|---|---|
|
||
| according to PDB 1ZT4 | ||
| other names |
R3G1 |
|
| Properties of human protein | ||
| Mass / length primary structure | 335 amino acids , 37,717 Da | |
| Identifier | ||
| External IDs | ||
Antigen-presenting glycoprotein CD1d is a surface protein .
properties
It is produced in cortical thymocytes and in some T-cell leukemias , among other things . CD1D is in the course of the adaptive immune response involved in the antigen presentation of lipid -, lipopeptide - and glycolipid - antigens compared to the T cell receptor of the NKT cells . In addition to lipids, it also binds to beta-2 microglobulin . CD1a is glycosylated and has disulfide bridges . It is also involved in cell adhesion .
Web links
Individual evidence
- ↑ RM McEwen-Smith, M. Salio, V. Cerundolo: CD1d-dependent endogenous and exogenous lipid antigen presentation. In: Current opinion in immunology. Volume 34, June 2015, pp. 116-125, doi : 10.1016 / j.coi.2015.03.004 , PMID 25805574 .
- ↑ J. Rossjohn, DG Pellicci, O. Patel, L. Gapin, DI Godfrey: Recognition of CD1d-restricted antigens by natural killer T cells. In: Nature Reviews Immunology . Volume 12, number 12, December 2012, pp. 845-857, doi : 10.1038 / nri3328 , PMID 23154222 , PMC 3740582 (free full text).