CD99
| CD99 antigen | ||
|---|---|---|
| other names |
12E7, E2 antigen, MIC2, T-cell surface glycoprotein E2, CD99 |
|
| Properties of human protein | ||
| Mass / length primary structure | 185 amino acids , 18,848 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 4267 | |
| Ensemble | ENSG00000002586 | |
| UniProt | P14209 | |
| Refseq (mRNA) | NM_001122898.2 | |
| Refseq (protein) | NP_001116370.1 | |
| PubMed search |
4267
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CD99 (synonym MIC2 ) is a surface protein from the group of transport proteins .
properties
CD99 is involved in cell migration and cell adhesion of T cells . It also serves to transport ganglioside GM1 and to cause caspase- independent cell death of T cells. Probably CD99 is in the change of the actin - cytoskeleton involved. CD99 is a tumor suppressor in osteosarcomas . CD99 is glycosylated and phosphorylated . CD99 inhibits the binding to integrin β-1 and thus the binding to the extracellular matrix .
Web links
Individual evidence
- ↑ Lee KJ, Lee SH, Yadav BK, Ju HM, Kim MS, Park JH, Jeoung D, Lee H, Hahn JH: The activation of CD99 inhibits cell-extracellular matrix adhesion by suppressing β (1) integrin affinity . In: BMB Rep . 45, No. 3, March 2012, pp. 159-64. doi : 10.5483 / BMBRep.2012.45.3.159 . PMID 22449702 .