Integrin β-1
| Integrin beta-1 | ||
|---|---|---|
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| according to PDB 1K11 | ||
| other names |
Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, CD29 |
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| Properties of human protein | ||
| Mass / length primary structure | 798 amino acids , 88,415 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 3688 | |
| Ensemble | ENSG00000150093 | |
| UniProt | P05556 | |
| Refseq (mRNA) | NM_002211.3 | |
| Refseq (protein) | NP_002202.2 | |
| PubMed search |
3688
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Integrin β-1 (synonymous CD29 ) is a surface protein and a cell adhesion molecule .
properties
Integrin β-1 binds to the amino acid sequence RGD and forms either with integrin α-1, α-2, α-10 or α-11 a heterodimeric receptor for collagen (binding sequence GFPGER). With α-2, α-3 , α-4, α-5, α-8, α-10, α-11 or α-V, it forms a heterodimeric receptor for fibronectin . With α-3 it forms a receptor for epiligrin , thrombospondin and CSPG4 . With α-4 it forms a receptor for fractalkines . With α-5 it forms a receptor for fibrinogen . With α-1, α-2, α-6 or α-7 it forms a receptor for laminin and with α-4 one for VCAM1 (binding sequence QIDS). With α-9 it forms a receptor for VCAM1, osteopontin and cytotactin (binding sequence AEIDGIEL). With α-V it forms a receptor for vitronectin . Integrin β-1 is involved in various cellular processes such as cyctokinesis and angiogenesis . It is glycosylated , phosphorylated , acetylated and has an isopeptide bond after sumoylation .
Web links
Individual evidence
- ↑ PJ Goodfellow, HA Nevanlinna, P. Gorman, D. Sheer, G. Lam, PN Goodfellow: Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2. In: Annals of Human Genetics. Volume 53, Pt January 1, 1989, pp. 15-22, PMID 2524991 .