CD49d

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Integrin alpha-4
other names

CD49 antigen-like family member D, integrin alpha-IV, VLA-4 subunit alpha, CD-antigen: CD49d

Existing structure data : PDB  3V4P , PDB  3V4V , PDB  4HKC

Properties of human protein
Mass / length primary structure 1,032 amino acids , 114,900 Da
Identifier
External IDs
Orthologue (human)
Entrez 3676
Ensemble ENSG00000115232
UniProt P13612
Refseq (mRNA) NM_000885.5
Refseq (protein) NP_000876.3
PubMed search 3676

Integrin α-4 (synonym CD49d ) is a surface protein from the group of integrins .

properties

Integrin α-4 is a cell adhesion molecule . Together with integrin beta-1 or integrin beta-7, it forms a heterodimeric receptor for fibronectin and VCAM1 . It binds to the amino acid sequence GluIleAspSer (QIDS) in fibronectin. Integrin α-4 is glycosylated and phosphorylated . In contrast to other alpha integrins, integrin alpha-4 does not contain an I domain and is not activated by proteolysis . The complex of alpha-4 and beta-1 is referred to as VLA-4 and binds to fractalkine and PLA2G2A at different binding sites, whereby the binding to PLA2G2A increases the affinity of the binding of fractalkine. The complex of alpha-4 and beta-7 binds the sequence LeuAspThr in MADCAM1 . Integrin α-4 is involved in the development of chronic lymphocytic leukemia . The antibody natalizumab binds to integrin α-4 and is used to treat multiple sclerosis .

Integrin α-4 binds to LGALS8 and paxillin .

Web links

Individual evidence

  1. ↑ C. Chen, S. Puvvada: Prognostic Factors for Chronic Lymphocytic Leukemia. In: Current hematologic malignancy reports. Volume 11, Number 1, February 2016, pp. 37-42, doi : 10.1007 / s11899-015-0294-x , PMID 26748932 .
  2. ↑ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y: Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis . In: J. Cell. Sci. . 113, No. Pt 13, 2000, pp. 2385-97. PMID 10852818 .
  3. ↑ Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH: Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding . In: J. Biol. Chem. . 276, No. 44, November 2001, pp. 40903-9. doi : 10.1074 / jbc.M102665200 . PMID 11533025 .
  4. ↑ Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH: A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration . In: J. Biol. Chem. . 277, No. 23, June 2002, pp. 20887-94. doi : 10.1074 / jbc.M110928200 . PMID 11919182 .