Chloromethyl group

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The blue- marked chloromethyl group in a Merrifield resin (above) and in chloroacetic acid (below)

The chloromethyl group , CH 2 −Cl, is a single-bonded radical in organic and macromolecular chemistry.

Manufacturing

Aromatic compounds can be chloromethylated by the Blanc reaction . A Merrifield resin for the Merrifield synthesis ( solid phase synthesis of peptides ) can be produced from a (possibly cross-linked) polystyrene resin .

Individual evidence

  1. ↑ Otto-Albrecht Neumüller (Ed.): Römpps Chemie-Lexikon. Volume 1: A-Cl. 8th revised and expanded edition. Franckh'sche Verlagshandlung, Stuttgart 1979, ISBN 3-440-04511-0 , pp. 723-724.
  2. ^ Siegfried Hauptmann : Organic Chemistry , 2nd Edition, VEB Deutscher Verlag für Grundstoffindindustrie, Leipzig, 1985, pp. 662–663, ISBN 3-342-00280-8 .