Concatamer

A concatamer (synonymous concatemer ) is a biopolymer with a series of repeating units, e.g. B. repetitive DNA (synonym tandem repeat DNA ) or proteins with repetitive amino acid sequences .

properties

Concatamers form a typical intermediate stage in rolling circle replication . Some viruses (especially bacteriophages ) produce in the course of their replication repetitive sequences of their genome to be packaged in the virion , which - before or during packaging - are split into individual repeat units by viral nucleases .

Individual evidence

↑ A. Basu, S. Mazor, JR Casey: Distance measurements within a concatamer of the plasma membrane Cl⁻ / HCO₃⁻ exchanger, AE1. In: Biochemistry . Volume 49, Number 43, November 2010, ISSN 1520-4995 , pp. 9226-9240, doi : 10.1021 / bi101134h , PMID 20828148 .
↑ H. Fujisawa, M. Morita: Phage DNA packaging. In: Genes to cells: devoted to molecular & cellular mechanisms. Volume 2, Number 9, September 1997, ISSN 1356-9597 , pp. 537-545, PMID 9413995 .
↑ VB Rao, M. Feiss: The bacteriophage DNA packaging motor. In: Annual Review of Genetics . Volume 42, 2008, ISSN 0066-4197 , pp. 647-681, doi : 10.1146 / annurev.genet.42.110807.091545 , PMID 18687036 .
↑ MJ Culyba, JE Harrison, Y. Hwang, FD Bushman: DNA cleavage by the A22R resolvase of vaccinia virus. In: Virology. Volume 352, Number 2, September 2006, ISSN 0042-6822 , pp. 466-476, doi : 10.1016 / j.virol.2006.05.007 , PMID 16781759 .
↑ G. Morissette, L. Flamand: Herpesviruses and chromosomal integration. In: Journal of virology. Volume 84, number 23, December 2010, ISSN 1098-5514 , pp. 12100-12109, doi : 10.1128 / JVI.01169-10 , PMID 20844040 , PMC 2976420 (free full text).

[1] A. Basu, S. Mazor, JR Casey: Distance measurements within a concatamer of the plasma membrane Cl⁻ / HCO₃⁻ exchanger, AE1. In: Biochemistry . Volume 49, Number 43, November 2010, ISSN 1520-4995 , pp. 9226-9240, doi : 10.1021 / bi101134h , PMID 20828148 .

[2] H. Fujisawa, M. Morita: Phage DNA packaging. In: Genes to cells: devoted to molecular & cellular mechanisms. Volume 2, Number 9, September 1997, ISSN 1356-9597 , pp. 537-545, PMID 9413995 .

[3] VB Rao, M. Feiss: The bacteriophage DNA packaging motor. In: Annual Review of Genetics . Volume 42, 2008, ISSN 0066-4197 , pp. 647-681, doi : 10.1146 / annurev.genet.42.110807.091545 , PMID 18687036 .

[4] MJ Culyba, JE Harrison, Y. Hwang, FD Bushman: DNA cleavage by the A22R resolvase of vaccinia virus. In: Virology. Volume 352, Number 2, September 2006, ISSN 0042-6822 , pp. 466-476, doi : 10.1016 / j.virol.2006.05.007 , PMID 16781759 .

[5] G. Morissette, L. Flamand: Herpesviruses and chromosomal integration. In: Journal of virology. Volume 84, number 23, December 2010, ISSN 1098-5514 , pp. 12100-12109, doi : 10.1128 / JVI.01169-10 , PMID 20844040 , PMC 2976420 (free full text).