Costamer
| Parent |
| Muscle fibrils |
| Gene Ontology |
|---|
| QuickGO |
Costamer structure in the quadriceps of the mouse.
Costamers (from Latin Costa, the rib) are protein complexes whose task in the striated muscles is to ensure the transfer of force from myofibrils to the extracellular matrix , which occurs when sarcomeres are contracted .
Proteins involved in the connection are integrin , vinculin , talin and focal adhesion kinase (FAK).
In addition to the more focally concentrated transmission structures of the costamers, there is another transmission option via the fine-meshed network consisting of dystrophin proteins, which link actin filaments with the sarcoglycans located in the cell wall .
Individual evidence
- ↑ AM Samarel: Costameres, focal adhesions, and cardiomyocyte mechanotransduction. In: American Journal of Physiology - Heart and Circulatory Physiology. Volume 289, Number 6, December 2005, pp. H2291-H2301, ISSN 0363-6135 . doi : 10.1152 / ajpheart.00749.2005 . PMID 16284104 .
- ↑ NL Estrella, FJ Naya: Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle. In: Cellular and molecular life sciences: CMLS. Volume 71, Number 9, May 2014, pp. 1641-1656, ISSN 1420-9071 . doi : 10.1007 / s00018-013-1512-0 . PMID 24218011 . PMC 3984630 (free full text).