Curcuper

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Curcuperin is a marketing term that is composed of components of the words curcumin and piperine and is used as a dietary supplement .

properties

Curcuperin names mixtures of substances with different compositions from these two ingredients in a mixing ratio that is considered useful as a dietary supplement. Curcumin as a turmeric extract or synthetically produced is the actual active ingredient in most areas of application. Piperine as an extract from black pepper or also from synthetic production increases the absorption of curcumin in the intestine . The typical piperine content is on the order of 1% to 3%.

The combination of curcumin and piperine is being investigated in relation to the treatment of malaria (in combination with artemisinin ) and to inhibit the production of certain inflammatory messengers in a high-fat diet. Curcumin and piperine can inhibit various detoxification enzymes in the liver, but they do not lead to an altered metabolism of midazolam , flurbiprofen and paracetamol .

Individual evidence

  1. ↑ P. Rasoanaivo, CW Wright, ML Willcox, B. Gilbert: Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. In: Malaria Journal . Volume 10 Suppl 1, 2011, p. S4. doi : 10.1186 / 1475-2875-10-S1-S4 . PMID 21411015 . PMC 3059462 (free full text).
  2. ↑ AM Neyrinck, M. Alligier, PB Memvanga, E. Névraumont, Y. Larondelle, V. Préat, PD Cani, NM Delzenne: Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue. In: PLOS ONE . Volume 8, number 11, 2013, p. E81252. doi : 10.1371 / journal.pone.0081252 . PMID 24260564 . PMC 3834320 (free full text).
  3. ↑ LP Volak, MJ Hanley, G. Masse, S. Hazarika, JS Harmatz, V. Badmaev, M. Majeed, DJ Greenblatt, MH Court: Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. In: British Journal of Clinical Pharmacology . Volume 75, Number 2, February 2013, pp. 450-462. doi : 10.1111 / j.1365-2125.2012.04364.x . PMID 22725836 . PMC 3579260 (free full text).