Cyclopyrrolone

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Cyclopyrrolones refers to a family of hypnotics and anxiolytic effective non-benzodiazepine agonists with a similar pharmacological profile as the benzodiazepines . They are not chemically related to these, but interact with the GABA receptor in a similar way.

Structure of pyrrol-2-one (pyrrolone)

Common to the active ingredients is an N-substituted and hydrogenated pyrrole-2-one structure to which a ring system with or without heteroatoms is fused .

Zopiclone is the best-known active ingredient in this class. Further representatives are:

  • Zopiclone

  • Pagoclone

  • Pazinaclone

  • Suproclone

  • Suriclone

It is now believed that the dependence potential which the benzodiazepines equivalent.

Trivia

In an episode of the series “Tatort” broadcast in June 2018, a substance called “cyclopyrrolone” was found in the blood of a corpse.

Individual evidence

  1. ↑ What is cyclopyrrolone, the sedative from the crime scene? In: Deutsche Apotheker-Zeitung . 4th June 2018.