DNA glycosylase
| DNA glycosylases | ||
|---|---|---|
| Enzyme classification | ||
| EC, category | 3.2.2.- , hydrolase | |
The DNA glycosylases are DNA repair enzymes that recognize and repair damage to DNA . They are part of the cell's base excision repair .
The glycosylases recognize damaged bases and remove them from their deoxyribose phosphate structure . This creates an AP site in the DNA (apyrimidine or apurine site). An endonuclease can now open the DNA strand at the defective site and remove the deoxyribose. A polymerase replaces the nucleoside and the DNA strand is closed by a DNA ligase .
Individual evidence
- ↑ RELIGIOUS, JC et al: DNA glycosylase recognition and catalysis. In: Curr Opin Struct Biol. 2004 Feb; 14 (1): 43-9.