Direct Analysis in Real Time

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For analysis, a tablet is placed in the sample chamber between the DART ion source (right) and the entrance to the mass spectrometer (left).

Direct Analysis in Real Time (DART) is a technique for generating ions under atmospheric pressure from solid, liquid and gaseous substances. This analytical method was developed in 2005 by J. Laramée and R. Cody and is marketed and distributed by JEOL and IonSense. This ionization technique was one of the first that did not require any additional sample preparation, but instead allowed the direct analysis of solid, liquid and gaseous materials in unchanged form. The ionization can be carried out directly on surfaces such as B. tablets or body fluids (blood, saliva or urine), glass, leaves or clothing. The ionization is a combination of thermal desorption and Penning ionization . This technology is used in the perfume industry as well as in the pharmaceutical industry or forensics.

Individual evidence

  1. ↑ RB Cody, JA Laramée, HD Durst: Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions . In: Anal. Chem. . 77, No. 8, 2005, pp. 2297-2302. doi : 10.1021 / ac050162j . PMID 15828760 .
  2. ↑ RB Cody, JA Laramée, JM Nilles, HD Durst: 2. Direct Analysis in Real Time (DARTtm) Mass Spectrometry . In: J EOL News , 2005
  3. ^ Marek Domin, Robert Cody: Ambient Ionization Mass Spectrometry . RSC, 2014, ISBN 978-1-84973-926-9 , doi : 10.1039 / 9781782628026 .
  4. ^ Roy Helmy, Wes Schafer, Leah Buhler, Stephen Marcinko, Brian Musselman, Erin Guidry, Herb Jenkins, Fred Fleitz, Christopher J. Welch: Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development . In: Organic Process Research & Development . 14, No. 2, February 10, 2010, pp. 386-392. doi : 10.1021 / op9002938 .