Dorothee Dormann

from Wikipedia, the free encyclopedia

Dorothee Dormann , b. Schmid (* 1976 in Schorndorf ) is a German biochemist and cell biologist (molecular neuroscience). Until 2007 she published under her maiden name Schmid.

Life

Dorothee Dormann studied biochemistry at the Eberhard-Karls-Universität Tübingen from 1996 and 1999/2000 at the University of North Carolina . In 2002 she received her diploma in Tübingen (with Ralph Steinman from Rockefeller University in New York), for which she received a prize from the University of Tübingen. She then went to Rockefeller University, where she received her doctorate in 2007 with Christian Münz . She then worked as a post-doctoral student with Christian Haass at the German Center for Neurodegenerative Diseases (DZNE) and the Ludwig Maximilians University in Munich . Since 2014 she has been group leader (Emmy Noether research group) at the Biomedzinisches Zentrum (BMC) and chair of cell biology.

They made significant advances in research into the causes of certain neurodegenerative diseases, specifically amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In both cases, deposits of the protein FUS (Fused in Sarcoma) play a role, which plays a role in gene transcription and binds to DNA. In diseases, the transport of FUS in the cell no longer works and they collect in clumps in the cytoplasm (stress granules, SG). Dormann investigated this mechanism and found that it is based on a phase separation similar to the separation of the aqueous phase and oil. In ALS, the errors in the transport of the FUS to the cell nucleus are triggered by a mutation in the FUS gene, so that FUS binds more weakly to the transport protein called transportin. According to Dormann, however, the transportin also acts as a stabilizer against the tendency of FUS to phase separate. In FTD, a post-translational modification of FUS is defective (arginine methylation).

She was in the German National Academic Foundation. In 2014 she received the Heinz Maier Leibnitz Prize . For 2019 she received the Paul Ehrlich and Ludwig Darmstaedter Prize for young talent .

Fonts (selection)

  • as D. Schmid with C. Paludan, C. Münz a. a .: Endogenous MHC class II processing of a viral nuclear antigen after autophagy, Science, Volume 307, 2005, pp. 593-596
  • as D. Schmid with M. Pypaert, C. Münz: MHC class II antigen loading compartments continuously receive input from autophagosomes, Immunity, Volume 26, 2007, pp. 79-92
  • with A. Capell, C. Haass u. a. : Proteolytic processing of TAR DNA Binding Protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin, J Neurochem., Volume 110, 2009, pp. 1082-1094
  • with R. Rodde, C. Haass u. a .: ALS-associated FUS mutations disrupt Transportin-mediated nuclear transport, EMBO J., Volume 29, 2010, pp. 2841-57
  • with C. Haass: TDP-43 and FUS - A nuclear affair, Trends Neurosci., Volume 34, 2011, pp. 339-348
  • with T. Madl, C. Haass u. a .: Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS, EMBO J., Volume 31, 2012, pp. 4258-4275
  • with E. Bentmann E, C. Haass u. a .: Requirements for stress granule recruitment of Fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43), J Biol Chem., Volume 287, 2012, pp 23079-2394
  • with E. Bentmann, C. Haass: Stress granules in neurodegeneration - lessons learned from FUS and TDP-43, FEBS J., Volume 280, 2013, pp. 4348–4370
  • with C. Haass: Fused in Sarcoma (FUS): An oncogene goes awry in neurodegeneration, Mol Cell Neurosci., Volume 56, 2013, pp. 475-486
  • with HA Bowden: Altered mRNP granule dynamics in FTLD pathogenesis, J Neurochem., Volume 138, 2016, Suppl 1, pp 112-133.
  • with H. Ederle: TDP-43 and FUS - en route from the nucleus to the cytoplasm, FEBS Letters, Volume 591, 2017, pp. 1489–1507
  • with M. Hofweber u. a .: Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation, Cell, Volume 173, Issue 3, 2018, pp. 706-719

Web links

Remarks

  1. ↑ Mario Hofweber, Saskia Hutten, Benjamin Bourgeois, Emil Spreitzer, Annika Niedner-Boblenz, Martina Schifferer, Marc-David Ruepp, Mikael Simons, Dierk Niessing, Tobias Madl, Dorothee Dormann: Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation, Cell, Volume 173, 2018, pp. 706-719. Summary in Luise Dirscherl, Neurodegenerative Diseases - Fatal Droplets, idw online
personal data
SURNAME Dormann, Dorothee
ALTERNATIVE NAMES Schmid, Dorothee
BRIEF DESCRIPTION German biochemist
DATE OF BIRTH 1976
PLACE OF BIRTH Schorndorf