Downstream Promoter Element

Overview of the consensus sequences of the four core promoter elements B recognition element (BRE) , TATA box , initiator motif (Inr) and downstream promoter element (DPE) .

Downstream Promoter Element (English, in German about ' downstream promoter element ', DPE) is an area of a promoter and the binding site for the transcription factor TFIID .

properties

The downstream promoter element is part of the core promoter in the range from about +28 to +33 after the start of transcription . Originally the consensus sequence was described as RGWCGTG, whereas today the consensus sequence RGWYV (T) is assumed. A typical linked sequence is A / GGA / TCGTG.

DPE have previously been found in Drosophila melanogaster and humans, but not in Saccharomyces cerevisiae .

history

DPE was first described in 1996 by TW Burke and James T. Kadonaga at the University of California, San Diego .

Individual evidence

^ ^A ^b Jennifer EF Butler, James T. Kadonaga: The RNA polymerase II core promoter: a key component in the regulation of gene expression . In: Genes & Development . 16, No. 20, October 15, 2002, pp. 2583-2592. doi : 10.1101 / gad.1026202 . PMID 12381658 .

↑ ^a ^b ^c Tamar Juven-Gershon, James T. Kadonaga: Regulation of Gene Expression via the Core Promoter and the Basal Transcriptional Machinery . In: Developmental Biology . 339, No. 2, March 15, 2010, pp. 225-229. doi : 10.1016 / j.ydbio.2009.08.009 . PMID 19682982 . PMC 2830304 (free full text).

↑ ^a ^b T.W. Burke, James T. Kadonaga: Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters . (PDF, 5.5 MB) In: Genes & Development . 10, No. 6, March 15, 1996, pp. 711-724. doi : 10.1101 / gad.10.6.711 . PMID 8598298 .

↑ James T. Kadonaga: The DPE, a core promoter element for transcription by RNA polymerase II Archived from the original on March 4, 2016. Information: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF, 0.9 MB) In: Experimental & Molecular Medicine . 34, No. 4, September 2002, pp. 259-264. PMID 12515390 . Retrieved April 5, 2014. @1@ 2

[Butler2002-1] A ^b Jennifer EF Butler, James T. Kadonaga: The RNA polymerase II core promoter: a key component in the regulation of gene expression . In: Genes & Development . 16, No. 20, October 15, 2002, pp. 2583-2592. doi : 10.1101 / gad.1026202 . PMID 12381658 .

[Juven-Gershon2010-2] Tamar Juven-Gershon, James T. Kadonaga: Regulation of Gene Expression via the Core Promoter and the Basal Transcriptional Machinery . In: Developmental Biology . 339, No. 2, March 15, 2010, pp. 225-229. doi : 10.1016 / j.ydbio.2009.08.009 . PMID 19682982 . PMC 2830304 (free full text).

[Burke1996-3] T.W. Burke, James T. Kadonaga: Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters . (PDF, 5.5 MB) In: Genes & Development . 10, No. 6, March 15, 1996, pp. 711-724. doi : 10.1101 / gad.10.6.711 . PMID 8598298 .