Transcription factor IID
The transcription factor IID (TFIID) is a DNA-binding protein complex in the cell nucleus of eukaryotes that is necessary for the transcription of almost all protein-coding genes read by RNA polymerase II . In particular, TFIID ensures exact positioning during reading. TFIID consists of up to two dozen individual proteins , depending on the organism .
The complex, which is completed before transcription, binds with its member TATA box binding protein (TBP) to the TATA box in the core promoter of the gene, or in the absence of a TATA box, to one of the other proteins Promoter. The TBP-TATA binding leads to an 80-degree bending of the DNA, which enables the further binding of the transcription factor TFIIA.
Core members of TFIID, which are found in all vertebrates, are (human gene / protein): TBP ( UniProt P20226 ), TAF1 ( UniProt P21675 ), TAF4 ( UniProt O00268 ), TAF4B ( UniProt Q92750 ), TAF5 ( UniProt Q15542 ), TAF6 ( UniProt P49848 ), TAF9 ( UniProt Q16594 ), TAF10 ( UniProt Q12962 ), TAF11 ( UniProt Q15544 ).
Individual evidence
- ↑ Reinberg / reactome: Recognition and Binding of Core Promoter Elements by TFIID ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
- ↑ reactome: ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. TFIID [nucleoplasm]]
- ↑ CORUM: Phylogenetic Conservation of TFIID
Web links
- CORUM: TFIID complex