Dysproteinemia
| Classification according to ICD-10 | |
|---|---|
| E88.0 | Dysproteinemia |
| ICD-10 online (WHO version 2019) | |
Dysproteinemia (Greek: prefix dys- = disorder, malformation, malfunction; -emia = "in the blood") is a disruption of the protein balance in the blood , in which there is a quantitative disproportion between the plasma proteins . In the blood plasma are essentially albumins and globulins (α, β- and γ-globulins) in front. They can be separated using serum electrophoresis and then quantified. Dysproteinemia can be congenital or acquired.
The most important representative of the congenital dysproteinemias is the α₁-1-antitrypsin deficiency . There are also numerous rarer congenital forms, e.g. B. defect dysproteinemia, analbuminemia and atransferrinemia .
Acquired dysproteinemia occurs as a result of various diseases. They arise in the context of paraneoplastic syndromes , inflammation, liver diseases, plasma protein losses (e.g. in nephrotic syndrome ) and antibody deficiency syndromes . Acquired dysproteinemia can also occur in numerous other diseases.
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- Siegenthaler (ed.). Clinical pathophysiology . 9th edition. Georg Thieme Verlag Stuttgart 2006. ISBN 3-13-449609-7
