Exposome

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The exposome is the totality of all non-genetic, endogenous and exogenous environmental influences to which an individual is exposed for a lifetime. In understanding the etiology of human diseases that always affect one subject, the consideration of the exposome overcomes a one-sided understanding of the genetic cause.

The originally English term Exposome is a trunk word consisting of Exposure and Genome and was published in a paper in 2005 by Chris Wild, Director of the International Agency for Research on Cancer .

Individual evidence

  1. ↑ SM Rappaport: Biomarkers intersect with the exposome. In: Biomarkers. 2012 Jun 7.
  2. ↑ JD Pleil: Categorizing biomarkers of the human exposome and developing metrics for assessing environmental sustainability. In: J Toxicol Env Health Pt B Crit Rev . 2012 May; 15, pp. 264-280.
  3. ↑ CP Wild: The expo some: from concept to utility. In: Int J Epidemiol. 2012 Feb; 41, pp. 24-32.
  4. ↑ A. Paoloni-Giacobino: Post decade genomic - the epigenome and expo some challenges. In: Swiss Med Wkly. 2011; 141, p. W13321.
  5. ↑ PJ Lioy, SM Rappaport: Exposure science and the expo some: an opportunity for coherence in the environmental health sciences. In: Environ Health Perspect . 2011; 119, pp. A466-A467.
  6. ^ A. Peters, G. Hoek, K. Katsouyanni: Understanding the link between environmental exposures and health: does the exposome promise too much? In: J Epidemiol Community Health. 2012; 66, pp. 103-105.
  7. ^ SM Rappaport. Implications of the exposome for exposure science. In: J Expo Sci Environ Epidemiol . 2011; 21, pp. 5-9.
  8. ↑ CP Wild. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. In: Cancer Epidemiol Biomarkers Prev . 2005; 14, pp. 1847-1850.
  9. ↑ Michael Quinion: EXPOSOME. Retrieved May 28, 2012 .