FADS2
| Fatty acid desaturase 2 | ||
|---|---|---|
| Properties of human protein | ||
| Identifier | ||
| Gene names | FADS2, LLCDL2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 1.14.19.3 | |
| Orthologue | ||
| human | mouse | |
| Entrez | 9415 | |
| UniProt | O95864 | |
| Refseq (mRNA) | NM_004265 | NM_019699 |
| Gene locus | Chr 11: 61.6 - 61.63 Mb | Chr 19: 10.14 - 10.18 Mb |
| PubMed search | 9415 |
|
FADS2 is a gene found in mammals , including humans , mice and rats .
The protein encoded by this gene belongs to the family of genes called fatty acid desaturases (FADS). Desaturase enzymes regulate the desaturation of fatty acids by introducing double bonds between certain carbon atoms of the fatty acyl chain. Members of the FADS family are fusion products of an N-terminal, cytochromic, b5-like component and a C-terminal, desaturation part spanning several membranes, both of which are characterized by preserved histidine motifs. This gene forms a group with family member FADS1 on 11q12-q13.1. This cluster is believed to have evolved through gene duplication based on its similar exon / intron organization.
Two studies were that the C mutation of FADS2 in contrast to G mutation in conjunction with breastfeeding to IQ increases by 7 points.
Individual evidence
- ↑ Rat Genome Database: FADS2 (fatty acid desaturase 2) Rattus norvegicus
- ↑ Entrez Gene: FADS1 fatty acid desaturase 1 . Retrieved December 28, 2010.
- ^ Gene governs IQ boost from breastfeeding
- ↑ Caspi A, Williams B, Kim-Cohen J, et al. : Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism . In: Proceedings of the National Academy of Sciences . 104, 2007, p. 18860. doi : 10.1073 / pnas.0704292104 . PMID 17984066 .