Fcγ receptor IIIa
| Fcγ receptor IIIa | ||
|---|---|---|
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| according to PDB 1E4J | ||
| other names |
CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, low affinity immunoglobulin gamma Fc region receptor III-A |
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| Properties of human protein | ||
| Mass / length primary structure | 254 amino acids , 29,089 Da | |
| Identifier | ||
| External IDs | ||
Fcγ receptor IIIa (synonym CD16a , FcγRIIIα ) is a surface protein from the group of Fc receptors .
properties
As an Fcγ receptor , CD16a binds with low affinity to the Fc region of immunoglobulin G , with or without bound antigens . It is made by NK cells , macrophages and some T cells and placental trophoblasts . CD16a is involved in antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis , in contrast to the closely related CD16b . CD16a contains an ITAM intracellularly and is glycosylated .
Web links
Individual evidence
- ↑ XY Li, L. Wu, SW Li, WB Zhou, MY Wang, GQ Zuo, CA Liu, X. Ding: Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells. In: International journal of molecular medicine. Volume 37, number 6, June 2016, pp. 1465–1474, doi : 10.3892 / ijmm.2016.2561 , PMID 27082928 , PMC 4866971 (free full text).
- ↑ P. Selvaraj, N. Fifadara, S. Nagarajan, A. Cimino, G. Wang: Functional regulation of human neutrophil Fc gamma receptors. In: Immunologic research. Volume 29, Numbers 1-3, 2004, pp. 219-230, doi : 10.1385 / IR: 29: 1-3: 219 , PMID 15181284 .